Abstract:
:Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis, before birth, to be able to intervene during the gestation or in the neonatal period. Human AFSCs (amniotic fluid stem cells), which have characteristics intermediate between those of embryonic and adult stem cells, have been isolated. c-Kit+Lin- cells derived from amniotic fluid display a multilineage haemopoietic potential and they can be easily reprogrammed to a pluripotent status. Although, in the future, we hope to use cells derived from the amniotic fluid, we and others have proved recently that simple organs such as the trachea can be engineered using adult progenitors utilizing decellularized cadaveric matrices. A similar approach could be used in the future for more complex organs such as the muscles, intestines or lungs.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
De Coppi Pdoi
10.1042/BST20140069subject
Has Abstractpub_date
2014-06-01 00:00:00pages
631-5issue
3eissn
0300-5127issn
1470-8752pii
BST20140069journal_volume
42pub_type
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20191046
更新日期:2020-04-29 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-12-15 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0351529
更新日期:2007-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0290571
更新日期:2001-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20110638
更新日期:2012-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0350599
更新日期:2007-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0361482
更新日期:2008-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0360033
更新日期:2008-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20160003
更新日期:2016-06-15 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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更新日期:2017-06-15 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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更新日期:2005-02-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2020-08-28 00:00:00
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更新日期:2003-12-01 00:00:00