Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.

Abstract:

:Protein phosphatase-6 (PP6) is a member of the PPP family of Ser/Thr phosphatases involved in intracellular signaling. PP6 is conserved among all eukaryotes, and genetics in model organisms indicates it has non-redundant functions relative to other PPP phosphatases. PP6 functions in association with conserved SAPS subunits and, in vertebrate species, forms heterotrimers with Ankrd subunits. Multiple studies have demonstrated how PP6 exerts negative control at different steps of nuclear factor kappaB signaling. Expression of PP6 catalytic subunit and the PPP6R1 subunit is especially high in hematopoietic cells and lymphoid tissues. Recent efforts at conditionally knocking out genes for PP6c or PP6R1 (SAPS1) have revealed distinctive effects on development of and signaling in lymphocytes.

journal_name

Biochem Soc Trans

authors

Ziembik MA,Bender TP,Larner JM,Brautigan DL

doi

10.1042/BST20160169

subject

Has Abstract

pub_date

2017-06-15 00:00:00

pages

693-701

issue

3

eissn

0300-5127

issn

1470-8752

pii

BST20160169

journal_volume

45

pub_type

杂志文章,评审
  • Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations.

    abstract::Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20051438

    authors: Meaburn KJ,Levy N,Toniolo D,Bridger JM

    更新日期:2005-12-01 00:00:00

  • Identification of secretin, vasoactive intestinal peptide and glucagon binding sites: from chimaeric receptors to point mutations.

    abstract::We have identified two basic residues that are important for the recognition of secretin and vasoactive intestinal peptide (VIP) by their respective receptors. These two peptides containing an Asp residue at position 3 interacted with an arginine residue in transmembrane helix 2 (TM2) of the receptor, and the lysine r...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0300437

    authors: Waelbroeck M,Perret J,Vertongen P,Van Craenenbroeck M,Robberecht P

    更新日期:2002-08-01 00:00:00

  • New strategies for cartilage regeneration exploiting selected glycosaminoglycans to enhance cell fate determination.

    abstract::Most research strategies for cartilage tissue engineering use extended culture with complex media loaded with costly GFs (growth factors) to drive tissue assembly and yet they result in the production of cartilage with inferior mechanical and structural properties compared with the natural tissue. Recent evidence sugg...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20140031

    authors: Ayerst BI,Day AJ,Nurcombe V,Cool SM,Merry CL

    更新日期:2014-06-01 00:00:00

  • Properties and inhibition of the first two enzymes of the non-mevalonate pathway of isoprenoid biosynthesis.

    abstract::Enzymes of the 1-deoxy-D-xylulose 5-phosphate/2-C-methylerythritol 4-phosphate (DOXP/MEP) pathway are targets for new herbicides and antibacterial drugs. Until now, no inhibitors for the DOXP synthase have been known of. We show that one of the breakdown products of the herbicide clomazone affects the DOXP synthase. O...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:

    authors: Mueller C,Schwender J,Zeidler J,Lichtenthaler HK

    更新日期:2000-12-01 00:00:00

  • Identifying plant cell-surface receptors: combining 'classical' techniques with novel methods.

    abstract::Cell-cell communication during development and reproduction in plants depends largely on a few phytohormones and many diverse classes of polymorphic secreted peptides. The peptide ligands are bound at the cell surface of target cells by their membranous interaction partners representing, in most cases, either receptor...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130251

    authors: Uebler S,Dresselhaus T

    更新日期:2014-04-01 00:00:00

  • all-D proline-rich cell-penetrating peptides: a preliminary in vivo internalization study.

    abstract::Proline-rich cell-penetrating peptides, particularly the SAP (sweet arrow peptide), (VRLPPP)(3), have been proposed to be useful intracellular delivery vectors, as a result of their lack of cytotoxicity combined with their capacity to be internalized by cells. A common limitation of the therapeutic use of peptides is ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0350794

    authors: Pujals S,Sabidó E,Tarragó T,Giralt E

    更新日期:2007-08-01 00:00:00

  • Translational control of synaptic plasticity.

    abstract::Synapses, points of contact between axons and dendrites, are conduits for the flow of information in the circuitry of the central nervous system. The strength of synaptic transmission reflects the interconnectedness of the axons and dendrites at synapses; synaptic strength in turn is modified by the frequency with whi...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0381527

    authors: Richter JD

    更新日期:2010-12-01 00:00:00

  • C/D box sRNA, CRISPR RNA and tRNA processing in an archaeon with a minimal fragmented genome.

    abstract::The analysis of deep sequencing data allows for a genome-wide overview of all the small RNA molecules (the 'sRNome') that are present in a single organism. In the present paper, we review the processing of CRISPR (clustered regularly interspaced short palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120276

    authors: Richter H,Mohr S,Randau L

    更新日期:2013-02-01 00:00:00

  • Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition.

    abstract::Human heparan sulphate N-deacetylase/N-sulphotransferase 1 sulphates the NH(3) (+) group of the glucosamine moiety of the heparan chain in heparan sulphate/heparin biosynthesis. An open cleft that runs perpendicular to the sulphate donor 3'-phosphoadenosine 5'-phosphosulphate may constitute the acceptor substrate-bind...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310331

    authors: Kakuta Y,Li L,Pedersen LC,Pedersen LG,Negishi M

    更新日期:2003-04-01 00:00:00

  • Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase.

    abstract::The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell motility in diverse organisms and cell types. In mammals, the main PI3K enzyme activated by chemokine receptor signalling is the class IB isoform, p110gamma. Studies of p110gamma-knockout mice have shown an essential function for this isoform i...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351109

    authors: Oak JS,Matheu MP,Parker I,Cahalan MD,Fruman DA

    更新日期:2007-11-01 00:00:00

  • The plant nuclear envelope in focus.

    abstract::Recent progress in understanding the plant NE (nuclear envelope) has resulted from significant advances in identifying and characterizing the protein constituents of the membranes and nuclear pores. Here, we review recent findings on the membrane integral and membrane-associated proteins of the key domains of the NE, ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380307

    authors: Graumann K,Evans DE

    更新日期:2010-02-01 00:00:00

  • Regulation of the pyruvate dehydrogenase complex.

    abstract::The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. T...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20060217

    authors: Patel MS,Korotchkina LG

    更新日期:2006-04-01 00:00:00

  • Polyunsaturated fatty acids and inflammation.

    abstract::The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a par...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0330423

    authors: Calder PC

    更新日期:2005-04-01 00:00:00

  • Actions of oestrogen on vascular endothelial and smooth-muscle cells.

    abstract::The overall effects of oestrogen on the vasculature are beneficial as a result of its antioxidant properties and ability to enhance relaxation by modulating synthesis of endothelium-derived vasodilators and smooth-muscle cell Ca2+ signalling. Although the protective effects of oestrogen are well accepted, only limited...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0250040

    authors: Ruehlmann DO,Mann GE

    更新日期:1997-02-01 00:00:00

  • The flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling.

    abstract::The Drosophila melanogaster flightless I protein and its homologues in higher eukaryotes (FliI) are conserved members of the gelsolin family of actin-binding proteins. Members of the gelsolin family generally contain three or six copies of a 125-amino-acid residue gelsolin-related repeating unit, and may contain addit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0320940

    authors: Archer SK,Behm CA,Claudianos C,Campbell HD

    更新日期:2004-12-01 00:00:00

  • The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.

    abstract::GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins, which mediate their effects by coupling with G-proteins. Despite responding to a range of very diverse stimuli, these receptors exhibit a conserved tertiary structure comprising a bundle of seven TM (transmembrane) helices linked ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0321048

    authors: Lawson Z,Wheatley M

    更新日期:2004-12-01 00:00:00

  • Emerging functions of alternative splicing coupled with nonsense-mediated decay.

    abstract::Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cy...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20140066

    authors: Hamid FM,Makeyev EV

    更新日期:2014-08-01 00:00:00

  • Cation transport by the respiratory NADH:quinone oxidoreductase (complex I): facts and hypotheses.

    abstract::The respiratory complex I (electrogenic NADH:quinone oxidoreductase) has been considered to act exclusively as a H+ pump. This was questioned when the search for the NADH-driven respiratory Na+ pump in Klebsiella pneumoniae initiated by Peter Dimroth led to the discovery of a Na+-translocating complex in this enteroba...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130024

    authors: Steffen W,Steuber J

    更新日期:2013-10-01 00:00:00

  • Role of class II phosphoinositide 3-kinase in cell signalling.

    abstract::Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0350211

    authors: Falasca M,Maffucci T

    更新日期:2007-04-01 00:00:00

  • Mechanisms of microbial escape from phagocyte killing.

    abstract::Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to av...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130014

    authors: Smith LM,May RC

    更新日期:2013-04-01 00:00:00

  • Regulation of gene expression by the RNA-binding protein Sam68 in cancer.

    abstract::Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the presen...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360505

    authors: Rajan P,Gaughan L,Dalgliesh C,El-Sherif A,Robson CN,Leung HY,Elliott DJ

    更新日期:2008-06-01 00:00:00

  • Collagen gene structure.

    abstract::The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence s...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0160661

    authors: Dalgleish R

    更新日期:1988-10-01 00:00:00

  • Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549.

    abstract::PGs (prostaglandins) are synthesized through the cyclo-oxygenase (COX-1 and -2) pathway in a variety of cells in response to various physiological stimuli. All cells require at least one pathway for apoptosis, and mitochondrial play a central role in regulation of apoptosis. In a previous study, incubation of A549 cel...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0321078

    authors: Fang KM,Shu WH,Chang HC,Wang JJ,Mak OT

    更新日期:2004-12-01 00:00:00

  • Effects of intra-gene fitness interactions on the benefit of sexual recombination.

    abstract::Whereas spontaneous point mutation operates on nucleotides individually, sexual recombination manipulates the set of nucleotides within an allele as an essentially particulate unit. In principle, these two different scales of variation enable selection to follow fitness gradients in two different spaces: in nucleotide...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0340560

    authors: Watson RA,Weinreich DM,Wakeley J

    更新日期:2006-08-01 00:00:00

  • Current understanding of plant Polycomb group proteins and the repressive histone H3 Lysine 27 trimethylation.

    abstract::Polycomb group (PcG) proteins are highly conserved chromatin-modifying complexes that implement gene silencing in higher eukaryotes. Thousands of genes and multiple developmental processes are regulated by PcG proteins. As the first chromatin modifier been identified in model plant Arabidopsis thaliana, the methyltran...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200192

    authors: Jiao H,Xie Y,Li Z

    更新日期:2020-08-28 00:00:00

  • Probing coupled motions in enzymatic hydrogen tunnelling reactions.

    abstract::Much work has gone into understanding the physical basis of the enormous catalytic power of enzymes over the last 50 years or so. Nevertheless, the detailed mechanism used by Nature's catalysts to speed chemical transformations remains elusive. DHFR (dihydrofolate reductase) has served as a paradigm to study the relat...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0370349

    authors: Allemann RK,Evans RM,Loveridge EJ

    更新日期:2009-04-01 00:00:00

  • Sodium chloride effects on lipase activity in germinating rape seeds.

    abstract::Seeds of rape (Brassica napus L.) were germinated at various NaCl concentrations up to 200 mM. Germinating levels, seedling growth, triacylglycerol mobilization and lipase activity were investigated. High salt concentrations resulted in retardation of seed germination. Seedling growth as measured by radicle length was...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:

    authors: Ben Miled DD,Zarrouk M,Chérif A

    更新日期:2000-12-01 00:00:00

  • Nutritional influences on the gut microbiota and the consequences for gastrointestinal health.

    abstract::The human colonic microbiota degrades dietary substrates that are indigestible in the upper GIT (gastrointestinal tract), releasing bacterial metabolites, some of which are important for gut health. Advances in molecular biology techniques have facilitated detailed analyses of the composition of the bacterial communit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0391073

    authors: Scott KP,Duncan SH,Louis P,Flint HJ

    更新日期:2011-08-01 00:00:00

  • Mass spectrometry approaches for vitamin E research.

    abstract::Vitamin E is an important nutrient with antioxidant and non-antioxidant functions, and certain evidence suggests that it has a cardiovascular protective role. It is therefore important to maintain an optimal vitamin E status. In the present paper, a number of MS applications to monitor vitamin E status and its interac...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0361066

    authors: Lodge JK

    更新日期:2008-10-01 00:00:00

  • Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.

    abstract::Accumulating evidence indicates that beta-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that beta-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcript...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360321

    authors: Eizirik DL,Moore F,Flamez D,Ortis F

    更新日期:2008-06-01 00:00:00