Abstract:
:Based on recent theoretical results on optimal flux distributions in kinetic metabolic networks, we explore the congruences and differences between solutions of kinetic optimization problems and results obtained by constraint-based methods. We demonstrate that, for a certain resource allocation problem, kinetic optimization and standard flux balance analysis (FBA) give rise to qualitatively different results. Furthermore, we introduce a variant of FBA, called satFBA, whose predictions are in qualitative agreement with kinetic optimization.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Müller S,Regensburger G,Steuer Rdoi
10.1042/BST20150156subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1195-200issue
6eissn
0300-5127issn
1470-8752pii
BST20150156journal_volume
43pub_type
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