Non-genomic progesterone signalling and its non-canonical receptor.

abstract：:mRNA instability is an intrinsic property that permits timely changes in gene expression by limiting the lifetime of a transcript. The RNase e of Escherichia coli is a single-strand-specific endo-nuclease involved in the processing of rRNA and the degradation of mRNA. A nucleolytic multi-enzyme complex now known as th...

journal_title：Biochemical Society transactions

authors： Carpousis AJ

更新日期：2002-04-01 00:00:00

abstract：:Biomarkers are needed to screen multiple stages in the clinical pathway of Barrett's oesophagus patients; from disease diagnosis to risk stratification and predicting response to therapy. Routes to the identification of biomarkers have been recognized by known molecular features of the disease and more recently throug...

journal_title：Biochemical Society transactions

authors： Huang Q,Hardie LJ

更新日期：2010-04-01 00:00:00

abstract：:Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular c...

journal_title：Biochemical Society transactions

authors： Pockley AG,Henderson B,Multhoff G

更新日期：2014-12-01 00:00:00

abstract：:AD (Alzheimer's disease) is a neurodegenerative disorder characterized by the abnormal hyperphosphorylation and aggregation of the microtubule-associated protein tau and the misfolding and deposition of Abeta peptide. The mechanisms by which tau and Abeta become abnormal is not clearly understood, neither is it known ...

journal_title：Biochemical Society transactions

authors： Cowan CM,Shepherd D,Mudher A

更新日期：2010-08-01 00:00:00

abstract：:Growth and differentiation factor-5 (GDF-5) is a divergent member of the transforming growth factor-beta/bone morphogenetic protein (BMP) superfamily that is required for proper skeletal patterning and development in the vertebrate limb. Based on the homology of GDF-5 with other bone-inducing BMP family members, the i...

journal_title：Biochemical Society transactions

authors： Spiro RC,Liu L,Heidaran MA,Thompson AY,Ng CK,Pohl J,Poser JW

更新日期：2000-01-01 00:00:00

abstract：:SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the ...

journal_title：Biochemical Society transactions

authors： Shih HM,Chang CC,Kuo HY,Lin DY

更新日期：2007-12-01 00:00:00

abstract：:PET (pre-eclamptic toxaemia), characterized by pregnancy-related hypertension and proteinuria, due to widespread endothelial dysfunction, is a primary cause of maternal morbidity. Altered circulating factors, particularly the VEGF (vascular endothelial growth factor) family of proteins and their receptors, are thought...

journal_title：Biochemical Society transactions

authors： Bates DO

更新日期：2011-12-01 00:00:00

abstract：:The recruitment of the furanosidic scaffold of ribose as the crucial step for nucleotides and then for nucleic acids synthesis is presented. Based on the view that the selection of molecules to be used for relevant metabolic purposes must favor structurally well-defined molecules, the inadequacy of ribose as a prefere...

journal_title：Biochemical Society transactions

authors： Del-Corso A,Cappiello M,Moschini R,Balestri F,Mura U,Ipata PL

更新日期：2019-12-20 00:00:00

abstract：:Post-transcriptional gene silencing (PTGS) has been successfully used to modify seed lipids in oilseed crops like soybean, canola and sunflower. Conventionally, PTGS has been induced by transforming the plants with either antisense or co-suppression constructs targeted against key seed lipid biosynthesis genes. A majo...

journal_title：Biochemical Society transactions

authors： Singh S,Green A,Stoutjesdijk P,Liu Q

更新日期：2000-12-01 00:00:00

abstract：:The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction)...

journal_title：Biochemical Society transactions

authors： Roos S,Powell TL,Jansson T

更新日期：2009-02-01 00:00:00

abstract：:A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled receptors) has been frustrated by the lack of clear homology between the respective sequences. Here, we review previous computational studies on GPCR dimerization in which the putative dimerization interfaces have been analysed u...

journal_title：Biochemical Society transactions

authors： Vohra S,Chintapalli SV,Illingworth CJ,Reeves PJ,Mullineaux PM,Clark HS,Dean MK,Upton GJ,Reynolds CA

更新日期：2007-08-01 00:00:00

abstract：:Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the po...

journal_title：Biochemical Society transactions

authors： Mehta IS,Elcock LS,Amira M,Kill IR,Bridger JM

更新日期：2008-12-01 00:00:00

abstract：:The methyl-CpG-binding protein MeCP2 was discovered over 15 years ago as part of a search for proteins that selectively bind methylated DNA. It is a nuclear protein that is largely chromatin-bound and has a strong preference for binding to methylated DNA sequences in vivo. Evidence from model systems shows that MeCP2 ...

journal_title：Biochemical Society transactions

authors： Bird A

更新日期：2008-08-01 00:00:00

abstract：:The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can ...

journal_title：Biochemical Society transactions

authors： Huvet M,Toni T,Tan H,Jovanovic G,Engl C,Buck M,Stumpf MP

更新日期：2009-08-01 00:00:00

abstract：:Isolation and purification of the [NiFe] hydrogenase of Desulfovibrio vulgaris Miyazaki F under aerobic conditions leads to a mixture of two states, Ni-A (unready) and Ni-B (ready). The two states are distinguished by different activation times and different EPR spectra. HYSCORE and ENDOR data and DFT calculations sho...

journal_title：Biochemical Society transactions

authors： van Gastel M,Fichtner C,Neese F,Lubitz W

更新日期：2005-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) were originally thought to only be released by phagocytic cells during their role in host defence. It is now clear that ROS have a cell signalling role in many biological systems, both in animals and in plants. ROS induce programmed cell death or necrosis, induce or suppress the expressio...

journal_title：Biochemical Society transactions

authors： Hancock JT,Desikan R,Neill SJ

更新日期：2001-05-01 00:00:00

abstract：:Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensiv...

journal_title：Biochemical Society transactions

authors： Brandon NJ

更新日期：2007-11-01 00:00:00

abstract：:The action of VEGF (vascular endothelial growth factor) is essential to maintain proper endothelial and vascular function. VEGF stimulates virtually all aspects of endothelial function, namely proliferation, migration, permeability and nitric oxide production and release. In addition, the action of VEGF makes the endo...

journal_title：Biochemical Society transactions

authors： Waltenberger J

更新日期：2009-12-01 00:00:00

abstract：:Biophysical techniques developed during the last three decades have provided an increasingly detailed description of the internal processes associated with ligand capture and release by haem proteins. Myoglobin has long been the paradigm for these studies. More recently, cytochrome P450cam (the camphor-metabolizing cy...

journal_title：Biochemical Society transactions

authors： Lavalette D,Tétreau C,Mouawad L

更新日期：2006-11-01 00:00:00

abstract：:The function of biomolecules is intrinsically linked to their structure and the complexes they form during function. Techniques for the determination of structures and dynamics of these nanometre assemblies are therefore important for an understanding on the molecular level. PELDOR (pulsed electron-electron double res...

journal_title：Biochemical Society transactions

authors： Reginsson GW,Schiemann O

更新日期：2011-01-01 00:00:00

abstract：:The EMLs are a conserved family of microtubule-associated proteins (MAPs). The founding member was discovered in sea urchins as a 77-kDa polypeptide that co-purified with microtubules. This protein, termed EMAP for echinoderm MAP, was the major non-tubulin component present in purified microtubule preparations made fr...

journal_title：Biochemical Society transactions

authors： Fry AM,O'Regan L,Montgomery J,Adib R,Bayliss R

更新日期：2016-10-15 00:00:00

abstract：:CoA (coenzyme A) and its derivatives have a critical role in regulating cardiac energy metabolism. This includes a key role as a substrate and product in the energy metabolic pathways, as well as serving as an allosteric regulator of cardiac energy metabolism. In addition, the CoA ester malonyl-CoA has an important ro...

journal_title：Biochemical Society transactions

authors： Abo Alrob O,Lopaschuk GD

更新日期：2014-08-01 00:00:00

abstract：:As intracellular pathogens, enveloped viruses must usurp the host cell machinery for many stages of the viral life cycle in order to produce a new generation of infectious virions. In one of the less understood steps of viral assembly, viral components including the transmembrane glycoproteins, structural proteins and...

journal_title：Biochemical Society transactions

authors： Bruce EA,Stuart A,McCaffrey MW,Digard P

更新日期：2012-12-01 00:00:00

abstract：:There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the beta-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven...

journal_title：Biochemical Society transactions

authors： Wisniewski T,Brown DR,Sigurdsson EM

更新日期：2002-08-01 00:00:00

abstract：:We recently showed that transport of ergosterol from the ER (endoplasmic reticulum) to the sterol-enriched PM (plasma membrane) in yeast occurs by a non-vesicular (Sec18p-independent) mechanism that results in the equilibration of sterol pools in the two organelles [Baumann, Sullivan, Ohvo-Rekilä, Simonot, Pottekat, K...

journal_title：Biochemical Society transactions

authors： Sullivan DP,Ohvo-Rekilä H,Baumann NA,Beh CT,Menon AK

更新日期：2006-06-01 00:00:00

abstract：:Within the SulfoSYS (Sulfolobus Systems Biology) project, the effect of temperature on a metabolic network is investigated at the systems level. Sulfolobus solfataricus utilizes an unusual branched ED (Entner-Doudoroff) pathway for sugar degradation that is promiscuous for glucose and galactose. In the course of metab...

journal_title：Biochemical Society transactions

authors： Haferkamp P,Kutschki S,Treichel J,Hemeda H,Sewczyk K,Hoffmann D,Zaparty M,Siebers B

更新日期：2011-01-01 00:00:00

abstract：:The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular s...

journal_title：Biochemical Society transactions

authors： Weaver LN,Walczak CE

更新日期：2015-02-01 00:00:00

abstract：:Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult...

journal_title：Biochemical Society transactions

authors： Falasca M,Maffucci T

更新日期：2007-04-01 00:00:00

abstract：:The adhesion of cells to the extracellular matrix is a dynamic process, mediated by a series of cell-surface and matrix-associated molecules that interact with each other in a spatially and temporally regulated manner. These interactions play a major role in tissue formation, cellular migration and the induction of ad...

journal_title：Biochemical Society transactions

authors： Zaidel-Bar R,Cohen M,Addadi L,Geiger B

更新日期：2004-06-01 00:00:00

abstract：:In vascular endothelium, adherens junctions between endothelial cells are composed of VE-cadherin (vascular endothelial cadherin), an adhesive receptor that is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity. As a classical cadherin, VE-cadherin links endothelial cells ...

journal_title：Biochemical Society transactions

authors： Taveau JC,Dubois M,Le Bihan O,Trépout S,Almagro S,Hewat E,Durmort C,Heyraud S,Gulino-Debrac D,Lambert O

更新日期：2008-04-01 00:00:00