Abstract:
:Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Pockley AG,Henderson B,Multhoff Gdoi
10.1042/BST20140205subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1744-51issue
6eissn
0300-5127issn
1470-8752pii
BST20140205journal_volume
42pub_type
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