PI3K-signalling in B- and T-cells: insights from gene-targeted mice.

Abstract:

:Phosphoinositide 3-kinases (PI3Ks) are important signalling enzymes in most cell types. Recent gene targeting studies have shed light on the importance of this family of lipid kinases in the immune system, and the complex mechanisms by which these kinases are regulated in vivo. We have recently reported a phenotype of mice in which the p110 delta PI3K catalytic subunit was inactivated by point mutation. In the present paper, we compare and contrast the phenotypes of p110 delta mutant mice with those of mice that lack p85 alpha or p110 gamma, and discuss these in the context of PI3K signalling in B- and T-cells.

journal_name

Biochem Soc Trans

authors

Okkenhaug K,Vanhaesebroeck B

doi

10.1042/bst0310270

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

270-4

issue

Pt 1

eissn

0300-5127

issn

1470-8752

journal_volume

31

pub_type

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