Abstract:
:Phosphoinositide 3-kinases (PI3Ks) are important signalling enzymes in most cell types. Recent gene targeting studies have shed light on the importance of this family of lipid kinases in the immune system, and the complex mechanisms by which these kinases are regulated in vivo. We have recently reported a phenotype of mice in which the p110 delta PI3K catalytic subunit was inactivated by point mutation. In the present paper, we compare and contrast the phenotypes of p110 delta mutant mice with those of mice that lack p85 alpha or p110 gamma, and discuss these in the context of PI3K signalling in B- and T-cells.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Okkenhaug K,Vanhaesebroeck Bdoi
10.1042/bst0310270keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
270-4issue
Pt 1eissn
0300-5127issn
1470-8752journal_volume
31pub_type
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