Abstract:
:AD (Alzheimer's disease) is a neurodegenerative disorder characterized by the abnormal hyperphosphorylation and aggregation of the microtubule-associated protein tau and the misfolding and deposition of Abeta peptide. The mechanisms by which tau and Abeta become abnormal is not clearly understood, neither is it known what role either protein plays in the neurodegenerative process underlying AD. We have modelled aspects of AD in Drosophila melanogaster to shed light on these processes and to further our understanding of the relationship between tau and amyloid in this disease.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Cowan CM,Shepherd D,Mudher Adoi
10.1042/BST0380988subject
Has Abstractpub_date
2010-08-01 00:00:00pages
988-92issue
4eissn
0300-5127issn
1470-8752pii
BST0380988journal_volume
38pub_type
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journal_title:Biochemical Society transactions
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