Abstract:
:The cell-cycle-co-ordinated initiation of chromosomal replication is highly regulated. The ordered assembly and conformational change of specific proteins at the replication origin are crucial to the process of replication initiation. In Escherichia coli, ATP-DnaA molecules form multimeric complexes with the chromosomal origin of replication (oriC), and unwind the duplex DNA within oriC, resulting in initiation of replication. DnaA is a common protein in bacterial species and plays a main and crucial role in the initiation of chromosomal replication. Unlike well-characterized AAA+ (ATPase associated with various cellular activities) proteins such as chaperons and proteases, DnaA molecules stably take on a monomeric form and form homomultimers in a manner dependent on binding to oriC. The oriC region carries several DnaA-binding sites with various affinities. Recent progress in the analysis of DnaA and related proteins has revealed specific roles for the AAA+ unique motifs of DnaA. These results suggest mechanisms for recognition of ATP bound to DnaA, the co-operative binding of ATP-DnaA molecules on oriC, the formation of an ATP-DnaA-specific oriC complex, an initiation complex and regulatory hydrolysis of DnaA-bound ATP.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Katayama Tdoi
10.1042/BST0360078subject
Has Abstractpub_date
2008-02-01 00:00:00pages
78-82issue
Pt 1eissn
0300-5127issn
1470-8752pii
BST0360078journal_volume
36pub_type
杂志文章abstract::The examples shown here illustrate the power of gene targeting to the epidermis as a means of developing animal models for the study of human skin diseases. In this short review, I have focused on contributions which stem predominantly from my own laboratory [31, 32, 34, 37, 47]. However, other laboratories have also ...
journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2013-02-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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