Abstract:
:Intracellular cross-talk or synergism between receptors coupled negatively to adenylate cyclase via PTX-sensitive Gi-protein(s) and receptors coupled to phospholipase C via PTX-insensitive G-proteins is prevalent in a variety of cell types (see above) and may represent a universal mechanism for the modulation of phospholipase C activity (and hence calcium mobilization). However, the precise mechanism(s) involved in these synergistic interactions remain to be unravelled. In view of the recent findings by Camps et al. (1992), it may be that Gi-protein-derived beta gamma subunits are responsible for the potentiation of phospholipase C activity observed in DDT1MF-2 cells (and other cell types). Clearly, the DDT1MF-2 smooth muscle cell line appears to provide an ideal model system in which to investigate the mechanisms underlying the intracellular cross-talk between receptors coupled to PTX-sensitive and to PTX-insensitive G-proteins.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Dickenson JM,Hill SJdoi
10.1042/bst0211124subject
Has Abstractpub_date
1993-11-01 00:00:00pages
1124-9issue
4eissn
0300-5127issn
1470-8752journal_volume
21pub_type
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