Abstract:
:The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular mechanisms. A number of studies have focused on endosomal sterol removal as its defects lead to cholesterol storage diseases. So far, the bulk of evidence on endosomal sterol egress describes the involvement of membrane trafficking machineries. Interestingly, two late endosomal sterol-binding proteins were recently shown to regulate the movement of late endosomes along cytoskeletal tracks. These studies provide the first indications of how non-vesicular and vesicular mechanisms may co-operate in endosomal sterol trafficking.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Hölttä-Vuori M,Ikonen Edoi
10.1042/BST0340392subject
Has Abstractpub_date
2006-06-01 00:00:00pages
392-4issue
Pt 3eissn
0300-5127issn
1470-8752pii
BST0340392journal_volume
34pub_type
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2011-10-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2006-11-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2007-11-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2004-06-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2004-04-01 00:00:00
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00