Abstract：
:Ligand-gated ion channels function as rapid signal transducers, converting chemical signals (in the form of neurotransmitters) into electrical signals in the postsynaptic neuron. This is achieved by the recognition of neurotransmitter at its specific-binding sites, which then triggers the opening of an ion channel ('gating'). For this to occur rapidly (< 1 ms), there must be an efficient coupling between the agonist-binding site and the gate, located more than 30 angstroms (1 angstroms = 0.1 nm) away. Whereas a great deal of progress has been made in elucidating the structure and function of both the agonist-binding site and the ion permeation pathway in ligand-gated ion channels, our knowledge of the coupling mechanism between these domains has been limited. In this review, we summarize recent studies of the agonist-binding site and the ion channel in the gamma-aminobutyric acid type A receptor, and discuss those structural elements that may mediate coupling between them. We will also consider some possible molecular mechanisms of receptor activation.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Kash TL,Trudell JR,Harrison NLdoi
10.1042/BST0320540keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
540-6issue
Pt3eissn
0300-5127issn
1470-8752pii
BST0320540journal_volume
32pub_type
杂志文章,评审abstract：:Insect and mammalian circadian clocks show striking similarities. They utilize homologous clock genes, generating self-sustained circadian oscillations in distinct master clocks of the brain, which then control rhythmic behaviour. The molecular mechanisms of rhythm generation were first uncovered in the fruit fly Dros...
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journal_title：Biochemical Society transactions
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Biochemical Society transactions
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journal_title：Biochemical Society transactions
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journal_title：Biochemical Society transactions
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更新日期：2015-06-01 00:00:00
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更新日期：1997-02-01 00:00:00
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doi：
更新日期：2000-12-01 00:00:00
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