An evolutionary perspective on protein moonlighting.

Abstract:

:Moonlighting proteins serve one or more novel functions in addition to their canonical roles. Moonlighting functions arise when an adventitious interaction between a protein and a new partner improves fitness of the organism. Selective pressure for improvement in the new function can result in two alternative outcomes. The gene encoding the newly bifunctional protein may duplicate and diverge so as to encode two proteins, each of which serves only one function. Alternatively, genetic changes that minimize adaptive conflict between the two functions and/or improve control over the time and place at which each function is served can lead to a moonlighting protein. Importantly, genetic changes that enhance a moonlighting function can occur in the gene encoding the moonlighting protein itself, in a gene that affects the structure of its new partner or in a gene encoding a transcription factor that controls expression of either partner. The evolutionary history of each moonlighting protein is complex, depending on the stochastic occurrence of genetic changes such as gene duplication and point mutations, and the effects of those changes on fitness. Population effects, particularly loss of promising individuals due to random genetic drift, also play a role in the emergence of a moonlighting protein. The ultimate outcome is not necessarily the 'optimal' solution to the problem of serving two functions, but may be 'good enough' so that fitness becomes limited by some other function.

journal_name

Biochem Soc Trans

authors

Copley SD

doi

10.1042/BST20140245

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1684-91

issue

6

eissn

0300-5127

issn

1470-8752

pii

BST20140245

journal_volume

42

pub_type

杂志文章,评审
  • The roles of the exoribonucleases DIS3L2 and XRN1 in human disease.

    abstract::RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 h...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20160107

    authors: Pashler AL,Towler BP,Jones CI,Newbury SF

    更新日期:2016-10-15 00:00:00

  • 3' Uridylation and the regulation of RNA function in the cytoplasm.

    abstract::Degradation of cytoplasmic mRNAs is an important aspect of the regulation of gene function in eukaryotes. Much of what is currently known about the underlying pathways of mRNA decay is derived from studies of the budding yeast Saccharomyces cerevisiae, in which mRNA turnover is initiated by deadenylation, followed eit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0381150

    authors: Norbury CJ

    更新日期:2010-08-01 00:00:00

  • Human mucin glycoproteins: varied structures predict diverse properties and specific functions.

    abstract::It has been clear for some time now that mucin glycoproteins have extensive, highly glycosylated tandem repeat domains. What is becoming increasingly apparent, however, is the diversity of unique sequences present on different mucins. Variations in mucin-unique sequences clearly result in major differences in physical...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0230795

    authors: Gum JR Jr

    更新日期:1995-11-01 00:00:00

  • Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases.

    abstract::The mitochondrial outer membrane separates the intermembrane space from the cytosol. The whole exchange of metabolites, cations and information between mitochondria and the cell occurs through the outer membrane. Experimental evidence is reviewed supporting the hypothesis of dynamic ADP compartmentation within the int...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0280164

    authors: Gellerich FN,Trumbeckaite S,Opalka JR,Seppet E,Rasmussen HN,Neuhoff C,Zierz S

    更新日期:2000-02-01 00:00:00

  • Current understanding of plant Polycomb group proteins and the repressive histone H3 Lysine 27 trimethylation.

    abstract::Polycomb group (PcG) proteins are highly conserved chromatin-modifying complexes that implement gene silencing in higher eukaryotes. Thousands of genes and multiple developmental processes are regulated by PcG proteins. As the first chromatin modifier been identified in model plant Arabidopsis thaliana, the methyltran...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200192

    authors: Jiao H,Xie Y,Li Z

    更新日期:2020-08-28 00:00:00

  • A new approach for the investigation of reperfusion-related brain injury.

    abstract::Effective stroke therapies require recanalization of occluded cerebral blood vessels; however, early reperfusion can cause BBB (blood-brain barrier) injury, leading to cerebral oedema and/or devastating brain haemorrhage. These complications of early reperfusion, which result from excess production of ROS (reactive ox...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0341366

    authors: Maier CM,Hsieh L,Crandall T,Narasimhan P,Chan PH

    更新日期:2006-12-01 00:00:00

  • The emerging molecular structure of the nitrogen cycle: an introduction to the proceedings of the 10th annual N-cycle meeting.

    abstract::Over the last 10 years, during the lifetime of the nitrogen cycle meetings, structural biology, coupled with spectroscopy, has had a major impact of our understanding enzymology of the nitrogen cycle. The three-dimensional structures for many of the key enzymes have now been resolved and have provided a wealth of info...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0330113

    authors: Butler CS,Richardson DJ

    更新日期:2005-02-01 00:00:00

  • The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.

    abstract::GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins, which mediate their effects by coupling with G-proteins. Despite responding to a range of very diverse stimuli, these receptors exhibit a conserved tertiary structure comprising a bundle of seven TM (transmembrane) helices linked ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0321048

    authors: Lawson Z,Wheatley M

    更新日期:2004-12-01 00:00:00

  • An unexpected tail of VEGF and PlGF in pre-eclampsia.

    abstract::PET (pre-eclamptic toxaemia), characterized by pregnancy-related hypertension and proteinuria, due to widespread endothelial dysfunction, is a primary cause of maternal morbidity. Altered circulating factors, particularly the VEGF (vascular endothelial growth factor) family of proteins and their receptors, are thought...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20110671

    authors: Bates DO

    更新日期:2011-12-01 00:00:00

  • Understanding non-coding DNA regions in yeast.

    abstract::Non-coding transcripts play an important role in gene expression regulation in all species, including budding and fission yeast. Such regulatory transcripts include intergenic ncRNA (non-coding RNA), 5' and 3' UTRs, introns and antisense transcripts. In the present review, we discuss advantages and limitations of rece...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130144

    authors: Schlackow M,Gullerova M

    更新日期:2013-12-01 00:00:00

  • Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.

    abstract::In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. Experimental data and computer simulations demonstrate that cross-talk is context-dependent and that both pathways can activate or inhibi...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20110609

    authors: Aksamitiene E,Kiyatkin A,Kholodenko BN

    更新日期:2012-02-01 00:00:00

  • The emerging complexity of protein ubiquitination.

    abstract::Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-translational modifications controlling intracellular signalling events. However, the ubiquitin system is vastly more complex compared with phosphorylation. This is due to the ability of ubiquitin to form polymers, i.e. ubiquitin ch...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0370937

    authors: Komander D

    更新日期:2009-10-01 00:00:00

  • Studies of focal adhesion assembly.

    abstract::Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction s...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360263

    authors: Campbell ID

    更新日期:2008-04-01 00:00:00

  • Regulation of chromosome dynamics by Hsk1/Cdc7 kinase.

    abstract::Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130217

    authors: Matsumoto S,Masai H

    更新日期:2013-12-01 00:00:00

  • Comparison of protein repeat classifications based on structure and sequence families.

    abstract::Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150079

    authors: Paladin L,Tosatto SC

    更新日期:2015-10-01 00:00:00

  • Synthetic biology meets tissue engineering.

    abstract::Classical tissue engineering is aimed mainly at producing anatomically and physiologically realistic replacements for normal human tissues. It is done either by encouraging cellular colonization of manufactured matrices or cellular recolonization of decellularized natural extracellular matrices from donor organs, or b...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150289

    authors: Davies JA,Cachat E

    更新日期:2016-06-15 00:00:00

  • Extracellular vesicles: translational challenges and opportunities.

    abstract::Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might be utilised as diagnostic and therapeutic tools. There remain, ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20180112

    authors: Clemmens H,Lambert DW

    更新日期:2018-10-19 00:00:00

  • Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling.

    abstract::ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the genera...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390674

    authors: Welham MJ,Kingham E,Sanchez-Ripoll Y,Kumpfmueller B,Storm M,Bone H

    更新日期:2011-04-01 00:00:00

  • Regulation of the pyruvate dehydrogenase complex.

    abstract::The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. T...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20060217

    authors: Patel MS,Korotchkina LG

    更新日期:2006-04-01 00:00:00

  • Mitochondrial respiration at low levels of oxygen and cytochrome c.

    abstract::In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/

    authors: Gnaiger E,Kuznetsov AV

    更新日期:2002-04-01 00:00:00

  • The many different cellular functions of MYO7A in the retina.

    abstract::Mutations in MYO7A (myosin VIIa) cause Usher syndrome type 1B, a disorder involving profound congenital deafness and progressive blindness. In the retina, most MYO7A is localized in the apical region of the RPE (retinal pigmented epithelial) cells, and a small amount is associated with the ciliary and periciliary memb...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0391207

    authors: Williams DS,Lopes VS

    更新日期:2011-10-01 00:00:00

  • Splitting up to heal: mitochondrial shape regulates signaling for focal membrane repair.

    abstract::Mitochondria are central to the health of eukaryotic cells. While commonly known for their bioenergetic role, mitochondria also function as signaling organelles that regulate cell stress responses capable of restoring homeostasis or leading the stressed cell to eventual death. Damage to the plasma membrane is a potent...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200120

    authors: Horn A,Jaiswal JK

    更新日期:2020-10-30 00:00:00

  • cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

    abstract::The PDE4 (phosphodiesterase-4) enzyme family consists of a distinct array of N-terminal splice variant isoforms arising from four subfamily genes (4A, 4B, 4C and 4D). These all hydrolyse specifically the intracellular second messenger cAMP. Although identical in catalytic function, each isoform appears to serve a non-...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0350938

    authors: Lynch MJ,Baillie GS,Houslay MD

    更新日期:2007-11-01 00:00:00

  • Mechanistic diversity and regulation of Type II fatty acid synthesis.

    abstract::Fatty acid biosynthesis is catalysed in most bacteria by a group of highly conserved proteins known as the Type II fatty acid synthase (FAS) system. The Type II system organization is distinct from its mammalian counterpart and offers several unique sites for selective inhibition by antibacterial agents. There has bee...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0301050

    authors: Marrakchi H,Zhang YM,Rock CO

    更新日期:2002-11-01 00:00:00

  • Biochemical characterization of human DNA polymerase iota provides clues to its biological function.

    abstract::The human RAD30B gene has recently been shown to encode a novel DNA polymerase, DNA polymerase iota (poliota). The role of poliota within the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterization in vitro. The aim of this short review is, therefore, to summar...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/0300-5127:0290183

    authors: Tissier A,Frank EG,McDonald JP,Vaisman A,Fernàndez de Henestrosa AR,Boudsocq F,McLenigan MP,Woodgate R

    更新日期:2001-05-01 00:00:00

  • The role of TOG domains in microtubule plus end dynamics.

    abstract::The XMAP215 (Xenopus microtubule-associated protein 215) and CLASP [CLIP-170 (cytoskeletal linker protein 170) associated protein] microtubule plus end tracking families play central roles in the regulation of interphase microtubule dynamics and the proper formation of mitotic spindle architecture and flux. XMAP215 me...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0371002

    authors: Slep KC

    更新日期:2009-10-01 00:00:00

  • The quest to achieve the detailed structural and functional characterization of CymA.

    abstract::Shewanella oneidensis MR-1 is a sediment organism capable of dissimilatory reduction of insoluble metal compounds such as those of Fe(II) and Mn(IV). This bacterium has been used as a model organism for potential applications in bioremediation of contaminated environments and in the production of energy in microbial f...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120114

    authors: Louro RO,Paquete CM

    更新日期:2012-12-01 00:00:00

  • A diversity of SERCA Ca2+ pump inhibitors.

    abstract::The SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) is probably the most extensively studied membrane protein transporter. There is a vast array of diverse inhibitors for the Ca2+ pump, and many have proved significant in helping to elucidate both the mechanism of transport and gaining conformational structures...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390789

    authors: Michelangeli F,East JM

    更新日期:2011-06-01 00:00:00

  • Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.

    abstract::Microvilli are found on the apical surface of epithelial cells. Recent studies on the microvillar proteins ezrin and EBP50 (ezrin/radixin/moesin-binding phosphoprotein of 50 kDa) have revealed both the dynamics and the regulation of microvillar components, and how a dynamic ezrin phosphocycle is necessary to confine m...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20130263

    authors: Viswanatha R,Bretscher A,Garbett D

    更新日期:2014-02-01 00:00:00

  • A progress report on the crystallographic studies on the B800-850 antenna complex from Rhodopseudomonas acidophila strain 10050.

    abstract::Large single crystals (up to 1 mm in each dimension) of the B800-850 antenna complex from Rhodopseudomonas acidophila strain 10050 have been grown in the presence of beta-octyl-glucoside. These crystals have the space group R32 and unit cell dimensions of a = b = 119.9 A and c = 297.0 A. Recently we have improved our ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/bst0210039

    authors: Cogdell RJ,Halloren E,Hawthornthwaite AM,Thunnissen MM,Freer AA,McDermott G,Guthrie N,Isaacs N,Lindsay JG,Papiz M

    更新日期:1993-02-01 00:00:00