SHP-1: the next checkpoint target for cancer immunotherapy?

abstract：:The mRNA coding for FGF-2 (fibroblast growth factor 2), a major angiogenic factor, is translated by an IRES (internal ribosome entry site)-dependent mechanism. We have studied the role of the IRES in the regulation of FGF-2 expression in vivo, under pathophysiological conditions, by creating transgenic mice lines expr...

journal_title：Biochemical Society transactions

authors： Gonzalez-Herrera IG,Prado-Lourenco L,Teshima-Kondo S,Kondo K,Cabon F,Arnal JF,Bayard F,Prats AC

更新日期：2006-02-01 00:00:00

abstract：:Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis...

journal_title：Biochemical Society transactions

authors： De Coppi P

更新日期：2014-06-01 00:00:00

abstract：:Genomic DNA is constantly under threat from intracellular and environmental factors that damage its chemical structure. Uncorrected DNA damage may impede cellular propagation or even result in cell death, making it critical to restore genomic integrity. Decades of research have revealed a wide range of mechanisms thro...

journal_title：Biochemical Society transactions

authors： Ghodke H,Ho H,van Oijen AM

更新日期：2018-02-19 00:00:00

abstract：:Post-translational modification (PTM) of histones has been investigated in eukaryotes for years, revealing its widespread occurrence and functional importance. Many PTMs affect chromatin folding and gene activity. Only recently the occurrence of such modifications has been recognized in bacteria. However, it is unclea...

journal_title：Biochemical Society transactions

authors： Dilweg IW,Dame RT

更新日期：2018-10-19 00:00:00

abstract：:The short consensus/complement repeat (SCR) domain (also known as the complement control protein domain) is the most abundant domain type in the complement system. Crystal and NMR structures for proteins that contain single and multiple SCR domains have now been published. These contain inter-SCR linkers of between th...

journal_title：Biochemical Society transactions

authors： Perkins SJ,Gilbert HE,Aslam M,Hannan J,Holers VM,Goodship TH

更新日期：2002-11-01 00:00:00

abstract：:Oral and maxillofacial surgery is often challenging due to defective bone healing owing to the microbial environment of the oral cavity, the additional involvement of teeth and esthetic concerns. Insufficient bone volume as a consequence of aging and some oral and maxillofacial surgical procedures, such as tumor resec...

journal_title：Biochemical Society transactions

authors： Liu L,Chen Y,Song D,Huang D

更新日期：2020-06-30 00:00:00

abstract：:Based on recent theoretical results on optimal flux distributions in kinetic metabolic networks, we explore the congruences and differences between solutions of kinetic optimization problems and results obtained by constraint-based methods. We demonstrate that, for a certain resource allocation problem, kinetic optimi...

journal_title：Biochemical Society transactions

authors： Müller S,Regensburger G,Steuer R

更新日期：2015-12-01 00:00:00

abstract：:The interaction of chemokines and GAGs (glycosaminoglycans) on endothelial surfaces is a crucial step for establishing a chemotactic gradient which leads to the functional presentation of chemokines to their GPCRs (G-protein-coupled receptors) and thus to activation of approaching leucocytes. Based on molecular modell...

journal_title：Biochemical Society transactions

authors： Potzinger H,Geretti E,Brandner B,Wabitsch V,Piccinini AM,Rek A,Kungl AJ

更新日期：2006-06-01 00:00:00

abstract：:There is strong evidence for an important role for increased COX (cyclo-oxygenase)-2 expression and PG (prostaglandin) E2 production in colorectal tumorigenesis. PGE(2) acts through four E-prostanoid receptors (EP1-4). COX-2 has therefore become a target for the potential chemoprevention and therapy of colorectal canc...

journal_title：Biochemical Society transactions

authors： Chell S,Patsos HA,Qualtrough D,H-Zadeh AM,Hicks DJ,Kaidi A,Witherden IR,Williams AC,Paraskeva C

更新日期：2005-08-01 00:00:00

abstract：:We have investigated the cellular distribution of p122RhoGAP, a GTPase-activating protein of Rho small GTPase and an activator of phospholipase C-delta(1). Immunofluorescence studies demonstrated that endogenous p122 is localized at the tips of actin stress fibres and co-localizes with vinculin in normal rat kidney ce...

journal_title：Biochemical Society transactions

authors： Kawai K,Yamaga M,Iwamae Y,Kiyota M,Kamata H,Hirata H,Homma Y,Yagisawa H

更新日期：2004-12-01 00:00:00

abstract：:Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis. The patients were diagnosed in adulthood with CN...

journal_title：Biochemical Society transactions

authors： Texel SJ,Xu X,Harris ZL

更新日期：2008-12-01 00:00:00

abstract：:Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translatio...

journal_title：Biochemical Society transactions

authors： Ray S,Catnaigh PÓ,Anderson EC

更新日期：2015-06-01 00:00:00

abstract：:The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases...

journal_title：Biochemical Society transactions

authors： Krapp A,Simanis V

更新日期：2008-06-01 00:00:00

abstract：:Biochemical features of renin have been studied. Determination of the amino acid sequence and catalytically essential groups in the active sites of mouse submandibular gland revealed the similarity of renin with acid proteases. Yet stringent substrate specificity, neutral pH optimum of its enzyme activity and the uniq...

journal_title：Biochemical Society transactions

authors： Inagami T,Misono KS,Chang JJ,Takii Y

更新日期：1984-12-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved lysosome-mediated degradation and recycling process, which functions in cellular homeostasis and stress adaptation. The process is highly dynamic and involves autophagosome synthesis, cargo recognition and transport, autophagosome-lysosome fusion, and cargo degradation. The mul...

journal_title：Biochemical Society transactions

authors： Yang KC,Sathiyaseelan P,Ho C,Gorski SM

更新日期：2018-02-19 00:00:00

abstract：:The Cat family of genes have revealed unexpected complexity and regulation. The first 5 years of research have been productive, yet many important questions remain to be addressed. A major problem for the field of amino acid transport is a severe paucity of data on the structure of these proteins and their arrangement...

journal_title：Biochemical Society transactions

authors： MacLeod CL

更新日期：1996-08-01 00:00:00

abstract：:The 26S proteasome is a non-lysosomal protease in the cytosol and nucleus of eukaryotic cells. Its main function is to mediate ubiquitin-dependent proteolysis. The 26S proteasome is a multimeric complex composed by the 20S proteasome CP (core particle) and the 19S RPs (regulatory particles). Although the atomic struct...

journal_title：Biochemical Society transactions

authors： Matias AC,Ramos PC,Dohmen RJ

更新日期：2010-02-01 00:00:00

abstract：:Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic gain of function (cytotoxicity associated with protein aggregates). Although potentially harmful, protein sequences predisposed to aggregati...

journal_title：Biochemical Society transactions

authors： Sanchez de Groot N,Torrent M,Villar-Piqué A,Lang B,Ventura S,Gsponer J,Babu MM

更新日期：2012-10-01 00:00:00

abstract：:Three mammalian expression systems suitable for expressing recombinant receptors have been described. Each is suited to a different aspect of the study of receptors and their behaviour. IRES-based vectors are ideal for creating stable mammalian cell lines suitable for screening receptors using a signalling readout. Un...

journal_title：Biochemical Society transactions

authors： Rhodes AD,Bevan N,Patel K,Lee M,Rees S

更新日期：1998-11-01 00:00:00

abstract：:The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids. L-amino acids appear to a...

journal_title：Biochemical Society transactions

authors： Conigrave AD,Mun HC,Brennan SC

更新日期：2007-11-01 00:00:00

abstract：:Mutations in the X-linked MECP2 gene are the primary cause of the severe autism spectrum disorder RTT (Rett syndrome). Deletion of Mecp2 in mice recapitulates many of the overt neurological features seen in humans, and the delayed onset of symptoms is accompanied by deficits in neuronal morphology and synaptic physiol...

journal_title：Biochemical Society transactions

authors： Cobb S,Guy J,Bird A

更新日期：2010-04-01 00:00:00

abstract：:After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of recent study results. We outline in this review how a neuroprotective candidate drug should be developed, beginning with a thorough preclinical evaluation according to the STAIR (Stroke Therapy Academic Industry Roundtab...

journal_title：Biochemical Society transactions

authors： Schäbitz WR,Fisher M

更新日期：2006-12-01 00:00:00

abstract：:GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins, which mediate their effects by coupling with G-proteins. Despite responding to a range of very diverse stimuli, these receptors exhibit a conserved tertiary structure comprising a bundle of seven TM (transmembrane) helices linked ...

journal_title：Biochemical Society transactions

authors： Lawson Z,Wheatley M

更新日期：2004-12-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype that lacks targeted therapy due to the absence of estrogen, progesterone, and HER2 receptors. Moreover, TNBC was shown to have a poor prognosis, since it involves aggressive phenotypes that confer significant hindrance to therapeutic treatme...

journal_title：Biochemical Society transactions

authors： Rajagopal T,Talluri S,Venkatabalasubramanian S,Dunna NR

更新日期：2020-12-01 00:00:00

abstract：:PABPs [poly(A)-binding proteins] bind to the poly(A) tail of eukaryotic mRNAs and are conserved in species ranging from yeast to human. The prototypical cytoplasmic member, PABP1, is a multifunctional RNA-binding protein with roles in global and mRNA-specific translation and stability, consistent with a function as a ...

journal_title：Biochemical Society transactions

authors： Smith RW,Blee TK,Gray NK

更新日期：2014-08-01 00:00:00

abstract：:Nicotinic ACh (acetylcholine) and 5-HT3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate that the channel lining domain of such receptors is formed by the alpha-helical M2 domain (second transmembrane...

journal_title：Biochemical Society transactions

authors： Peters JA,Carland JE,Cooper MA,Livesey MR,Deeb TZ,Hales TG,Lambert JJ

更新日期：2006-11-01 00:00:00

abstract：:Molecular dynamics simulations may be used to probe the interactions of membrane proteins with lipids and with detergents at atomic resolution. Examples of such simulations for ion channels and for bacterial outer membrane proteins are described. Comparison of simulations of KcsA (an alpha-helical bundle) and OmpA (a ...

journal_title：Biochemical Society transactions

authors： Sansom MS,Bond PJ,Deol SS,Grottesi A,Haider S,Sands ZA

更新日期：2005-11-01 00:00:00

abstract：:Yeast cells rely on the SPS-sensing pathway to respond to extracellular amino acids. This nutrient-induced signal transduction pathway regulates gene expression by controlling the activity of two redundant transcription factors: Stp1 and Stp2. These factors are synthesized as latent cytoplasmic proteins with N-termina...

journal_title：Biochemical Society transactions

authors： Ljungdahl PO

更新日期：2009-02-01 00:00:00

abstract：:In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early T cell development to enable β-selection. Errors in ...

journal_title：Biochemical Society transactions

authors： Chann AS,Russell SM

更新日期：2019-08-30 00:00:00

abstract：:Biotin, which serves as a carboxyl group carrier in reactions catalyzed by biotin-dependent carboxylases, is essential for life in most organisms. To function in carboxylate transfer, the vitamin must be post-translationally linked to a specific lysine residue on the biotin carboxyl carrier (BCC) of a carboxylase in a...

journal_title：Biochemical Society transactions

authors： Beckett D

更新日期：2018-12-17 00:00:00