Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs.

abstract：:Muscles are responsible for generating the forces required for the movement of multicellular organisms. Microscopically, these forces arise as a consequence of motor proteins (myosin) pulling and sliding along actin filaments. Current knowledge states that the molecular forces between actin and myosin are linear in na...

journal_title：Biochemical Society transactions

authors： Nielsen BG

更新日期：2004-11-01 00:00:00

abstract：:Recent findings that some 24 inherited diseases and anomalies are caused by defects in proteins of the NE (nuclear envelope) and lamina have resulted in a fundamental reassessment of the functions of the NE and underlying lamina. Instead of just regarding the NE and lamina as a molecular filtering device, regulating t...

journal_title：Biochemical Society transactions

authors： Cohen TV,Hernandez L,Stewart CL

更新日期：2008-12-01 00:00:00

abstract：:The SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) is probably the most extensively studied membrane protein transporter. There is a vast array of diverse inhibitors for the Ca2+ pump, and many have proved significant in helping to elucidate both the mechanism of transport and gaining conformational structures...

journal_title：Biochemical Society transactions

authors： Michelangeli F,East JM

更新日期：2011-06-01 00:00:00

abstract：:Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction s...

journal_title：Biochemical Society transactions

authors： Campbell ID

更新日期：2008-04-01 00:00:00

abstract：:The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinit...

journal_title：Biochemical Society transactions

authors： Mayans O,Benian GM,Simkovic F,Rigden DJ

更新日期：2013-08-01 00:00:00

abstract：:Identified five decades ago amongst the most abundant cellular RNAs, small nucleolar RNAs (snoRNAs) were initially described as serving as guides for the methylation and pseudouridylation of ribosomal RNA through direct base pairing. In recent years, however, increasingly powerful high-throughput genomic approaches an...

journal_title：Biochemical Society transactions

authors： Bergeron D,Fafard-Couture É,Scott MS

更新日期：2020-04-29 00:00:00

abstract：:Diet can significantly influence exercise performance. Diet alone will not ensure successful performance in sport, but it plays a permissive role in allowing sustained intensive training with limited risk of illness and injury. Diet may also promote adaptations to training by stimulating synthesis and breakdown of the...

journal_title：Biochemical Society transactions

authors： Maughan RJ

更新日期：2003-12-01 00:00:00

abstract：:Voltage-gated K(+) channels are key regulators of neuronal excitability. The Kv2.1 voltage-gated K(+) channel is the major delayed rectifier K(+) channel expressed in most central neurons, where it exists as a highly phosphorylated protein. Kv2.1 plays a critical role in homoeostatic regulation of intrinsic neuronal e...

journal_title：Biochemical Society transactions

authors： Mohapatra DP,Park KS,Trimmer JS

更新日期：2007-11-01 00:00:00

abstract：:It is now clear that NSPs (neutrophil serine proteases), including elastase, Pr3 (proteinase 3) and CatG (cathepsin G) are major pathogenic determinants in chronic inflammatory disorders of the lungs. Two unglycosylated natural protease inhibitors, SLPI (secretory leucocyte protease inhibitor) and elafin, and its prec...

journal_title：Biochemical Society transactions

authors： Zani ML,Tanga A,Saidi A,Serrano H,Dallet-Choisy S,Baranger K,Moreau T

更新日期：2011-10-01 00:00:00

abstract：:UBDs [Ub (ubiquitin)-binding domains], which are typically small protein motifs of <50 residues, are used by receptor proteins to transduce post-translational Ub modifications in a wide range of biological processes, including NF-κB (nuclear factor κB) signalling and proteasomal degradation pathways. More than 20 fami...

journal_title：Biochemical Society transactions

authors： Searle MS,Garner TP,Strachan J,Long J,Adlington J,Cavey JR,Shaw B,Layfield R

更新日期：2012-04-01 00:00:00

abstract：:HD (Huntington's disease) is a late onset heritable neurodegenerative disorder that is characterized by neuronal dysfunction and death, particularly in the cerebral cortex and medium spiny neurons of the striatum. This is followed by progressive chorea, dementia and emotional dysfunction, eventually resulting in death...

journal_title：Biochemical Society transactions

authors： Bithell A,Johnson R,Buckley NJ

更新日期：2009-12-01 00:00:00

abstract：:There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a k...

journal_title：Biochemical Society transactions

authors： Tabner BJ,El-Agnaf OM,German MJ,Fullwood NJ,Allsop D

更新日期：2005-11-01 00:00:00

abstract：:ATP-binding cassette (ABC) transporters play crucial roles in cellular processes, such as nutrient uptake, drug resistance, cell-volume regulation and others. Despite their importance, all proposed molecular models for transport are based on indirect evidence, i.e. functional interpretation of static crystal structure...

journal_title：Biochemical Society transactions

authors： Husada F,Gouridis G,Vietrov R,Schuurman-Wolters GK,Ploetz E,de Boer M,Poolman B,Cordes T

更新日期：2015-10-01 00:00:00

abstract：:Membrane contact sites (MCSs) are subcellular regions where the membranes of distinct organelles come into close apposition. These specialized areas of the cell, which are involved in inter-organelle metabolite exchange, are scaffolded by specific complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-relate...

journal_title：Biochemical Society transactions

authors： Wilhelm LP,Tomasetto C,Alpy F

更新日期：2016-04-15 00:00:00

abstract：:VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) assoc...

journal_title：Biochemical Society transactions

authors： Koch S

更新日期：2012-02-01 00:00:00

abstract：:There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the beta-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven...

journal_title：Biochemical Society transactions

authors： Wisniewski T,Brown DR,Sigurdsson EM

更新日期：2002-08-01 00:00:00

abstract：:Biological diversity in marine OMZs (oxygen minimum zones) is dominated by a complex community of bacteria and archaea whose anaerobic metabolisms mediate key steps in global nitrogen and carbon cycles. Molecular and physiological studies now confirm that OMZs also support diverse micro-organisms capable of utilizing ...

journal_title：Biochemical Society transactions

authors： Stewart FJ

更新日期：2011-12-01 00:00:00

abstract：:Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensiv...

journal_title：Biochemical Society transactions

authors： Brandon NJ

更新日期：2007-11-01 00:00:00

abstract：:CoA (coenzyme A) is a ubiquitous and essential cofactor that acts as an acyl group carrier in biochemical reactions. Apart from participating in numerous metabolic pathways as substrates and intermediates, CoA and a number of its thioester derivatives, such as acetyl-CoA, can also directly regulate the activity of pro...

journal_title：Biochemical Society transactions

authors： Tsuchiya Y,Pham U,Gout I

更新日期：2014-08-01 00:00:00

abstract：:JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that the removal of specific Jnk genes can reduce neuronal death ass...

journal_title：Biochemical Society transactions

authors： Davies C,Tournier C

更新日期：2012-02-01 00:00:00

abstract：:In nearly all somatic cells, the ribosome biosynthesis is a key activity. The same is true also for mammalian oocytes and early embryos. This activity is intimately linked to the most prominent nuclear organelles - the nucleoli. Interestingly, during a short period around fertilization, the nucleoli in oocytes and emb...

journal_title：Biochemical Society transactions

authors： Fulka H,Rychtarova J,Loi P

更新日期：2020-04-29 00:00:00

abstract：:Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their...

journal_title：Biochemical Society transactions

authors： Venkatakrishnan AJ,Levy ED,Teichmann SA

更新日期：2010-08-01 00:00:00

abstract：:We have isolated a novel gene (GLELO) from Mortierella alpina and its homologue (CEELO1) from Caenorhabditis elegans and demonstrate the involvement of their encoded proteins in the elongation of C(18) polyunsaturated fatty acids. ...

journal_title：Biochemical Society transactions

authors： Das T,Thurmond JM,Bobik E,Leonard AE,Parker-Barnes JM,Huang YS,Mukerji P

更新日期：2000-12-01 00:00:00

abstract：:Numerous RNA molecules with new catalytic properties have been isolated from synthetic combinatorial libraries. A broad range of chemical reactions is catalysed, and nucleic acids can accelerate bond formation between small organic substrates. This review focuses on carbon-carbon bond formation accelerated by in vitro...

journal_title：Biochemical Society transactions

authors： Jäschke A,Stuhlmann F,Bebenroth D,Keiper S,Wombacher R

更新日期：2002-11-01 00:00:00

abstract：:Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-translational modifications controlling intracellular signalling events. However, the ubiquitin system is vastly more complex compared with phosphorylation. This is due to the ability of ubiquitin to form polymers, i.e. ubiquitin ch...

journal_title：Biochemical Society transactions

authors： Komander D

更新日期：2009-10-01 00:00:00

abstract：:Frequent subversion of the PI3K (phosphoinositide 3-kinase) pathway during neoplastic transformation contributes to several hallmarks of cancer that result in a competitive advantage for cancer cells. Deregulation of this pathway can be the result of genomic alterations such as PIK3CA mutation, PTEN (phosphatase and t...

journal_title：Biochemical Society transactions

authors： Leroy C,Amante RJ,Bentires-Alj M

更新日期：2014-08-01 00:00:00

abstract：:Phosphorylation by protein kinases is a fundamental mechanism of signal transduction. Many kinase families contain one or several members that, although evolutionarily conserved, lack the residues required for catalytic activity. Studies combining structural, biochemical, and functional approaches revealed that these ...

journal_title：Biochemical Society transactions

authors： Elías-Villalobos A,Fort P,Helmlinger D

更新日期：2019-12-20 00:00:00

abstract：:The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families, mutations in LRRK2 can cause PD with age-dependent but variable penetrance and genome-wide association studies have found variants of the g...

journal_title：Biochemical Society transactions

authors： Kluss JH,Mamais A,Cookson MR

更新日期：2019-04-30 00:00:00

abstract：:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

journal_title：Biochemical Society transactions

authors： Deranieh RM,Greenberg ML

更新日期：2009-10-01 00:00:00

abstract：:Prelamin A is the precursor protein of lamin A, a major constituent of the nuclear lamina in higher eukaryotes. Increasing attention to prelamin A processing and function has been given after the discovery, from 2002 to 2004, of diseases caused by prelamin A accumulation. These diseases, belonging to the group of lami...

journal_title：Biochemical Society transactions

authors： Lattanzi G

更新日期：2011-12-01 00:00:00