Abstract：
:There is strong evidence for an important role for increased COX (cyclo-oxygenase)-2 expression and PG (prostaglandin) E2 production in colorectal tumorigenesis. PGE(2) acts through four E-prostanoid receptors (EP1-4). COX-2 has therefore become a target for the potential chemoprevention and therapy of colorectal cancer. However, any therapeutic/preventive strategy has the potential to have an impact on physiological processes and hence result in side effects. General COX (COX-1 and -2) inhibition by traditional NSAIDs (non-steroidal anti-inflammatory drugs), such as aspirin, although chemopreventive, has some side effects, as do some conventional COX-2-selective NSAIDs. As PGE2 is thought to be the major PG species responsible for promoting colorectal tumorigenesis, research is being directed to a number of protein targets downstream of COX-2 that might allow the selective inhibition of the tumour-promoting activities of PGE2, while minimizing the associated adverse events. The PGE synthases and E-prostanoid receptors (EP1-4) have therefore recently attracted considerable interest as potential novel targets for the prevention/therapy of colorectal cancer. Selective (and possibly combinatorial) inhibition of the synthesis and signalling of those PGs most highly associated with colorectal tumorigenesis may have some advantages over COX-2-selective inhibitors.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Chell S,Patsos HA,Qualtrough D,H-Zadeh AM,Hicks DJ,Kaidi A,Witherden IR,Williams AC,Paraskeva Cdoi
10.1042/BST0330667keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
667-71issue
Pt 4eissn
0300-5127issn
1470-8752pii
BST0330667journal_volume
33pub_type
杂志文章,评审abstract：:Large dense-core vesicles (LDCVs) were labelled in cultured bovine adrenal chromaffin cells expressing fluorescent chimaeric 'cargo' proteins that were targeted to these secretory vesicles. When the cells were stimulated with nicotine 48 h after transduction, the fractional loss of fluorescent LDCVs was much greater t...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0310851
更新日期：2003-08-01 00:00:00
abstract：:Although the Gompertz formula accurately describes observed mortality distributions over most of their extent, their 'tail' is much longer than that of a Gompertz curve fitted to the whole data set. A simple candidate explanation is that the longest-lived subset of any population will necessarily be enriched in indivi...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/bst0310452
更新日期：2003-04-01 00:00:00
abstract：:Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0360272
更新日期：2008-06-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0310040
更新日期：2003-02-01 00:00:00
abstract：:Anaphase B spindle elongation plays an important role in chromosome segregation. In the present paper, we discuss our model for anaphase B in Drosophila syncytial embryos, in which spindle elongation depends on an ip (interpolar) MT (microtubule) sliding filament mechanism generated by homotetrameric kinesin-5 motors ...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0391149
更新日期：2011-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20050916
更新日期：2005-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0340931
更新日期：2006-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0320617
更新日期：2004-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0330493
更新日期：2005-06-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/bst0161081a
更新日期：1988-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/0300-5127:0280601
更新日期：2000-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20120226
更新日期：2013-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0310806
更新日期：2003-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0381337
更新日期：2010-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20180414
更新日期：2019-08-30 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20191084
更新日期：2020-06-30 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0300705
更新日期：2002-08-01 00:00:00
abstract：:Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activati...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0301091
更新日期：2002-11-01 00:00:00
abstract：:The methyl-CpG-binding protein MeCP2 was discovered over 15 years ago as part of a search for proteins that selectively bind methylated DNA. It is a nuclear protein that is largely chromatin-bound and has a strong preference for binding to methylated DNA sequences in vivo. Evidence from model systems shows that MeCP2 ...
journal_title：Biochemical Society transactions
pub_type：
doi：10.1042/BST0360575
更新日期：2008-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2004-04-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2009-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2004-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2001-08-01 00:00:00
abstract：:Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the po...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0361384
更新日期：2008-12-01 00:00:00
abstract：:Mass spectrometry (MS) provides an impressive array of information about the structure, function and interactions of proteins. In recent years, many new developments have been in the field of native MS and these exemplify a new coming of age of this field. In this mini review, we connect the latest methodological and ...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2019-02-28 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20150109
更新日期：2015-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20160003
更新日期：2016-06-15 00:00:00
abstract：:Changes in mitochondrial superoxide and hydrogen peroxide production may contribute to various pathologies, and even aging, given that over time and in certain conditions, they damage macromolecules and disrupt normal redox signalling. Mitochondria-targeted antioxidants such as mitoQ, mitoVitE, and mitoTEMPO have open...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20190305
更新日期：2019-10-31 00:00:00
