Polyphosphate and acidocalcisomes.

Abstract:

:Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H(+)-PPase or VP1), the vacuolar proton ATPase (V-H(+)-ATPase) or both, maintain their acidity. A vacuolar transporter chaperone (VTC) complex is involved in the synthesis and translocation of polyP to these organelles in several eukaryotes, such as yeast, trypanosomatids, Apicomplexan and algae. Studies in trypanosomatids have revealed the role of polyP and acidocalcisomes in osmoregulation and calcium signalling.

journal_name

Biochem Soc Trans

authors

Lander N,Cordeiro C,Huang G,Docampo R

doi

10.1042/BST20150193

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

1-6

issue

1

eissn

0300-5127

issn

1470-8752

pii

BST20150193

journal_volume

44

pub_type

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