Abstract:
:Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H(+)-PPase or VP1), the vacuolar proton ATPase (V-H(+)-ATPase) or both, maintain their acidity. A vacuolar transporter chaperone (VTC) complex is involved in the synthesis and translocation of polyP to these organelles in several eukaryotes, such as yeast, trypanosomatids, Apicomplexan and algae. Studies in trypanosomatids have revealed the role of polyP and acidocalcisomes in osmoregulation and calcium signalling.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Lander N,Cordeiro C,Huang G,Docampo Rdoi
10.1042/BST20150193subject
Has Abstractpub_date
2016-02-01 00:00:00pages
1-6issue
1eissn
0300-5127issn
1470-8752pii
BST20150193journal_volume
44pub_type
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