Abstract:
:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing molecules, including phosphoinositides and inositol phosphates, have signalling and regulatory roles in many cellular processes. This suggests that depleting inositol may lead to perturbation of a wide range of cellular functions, at least some of which may be associated with bipolar disorder.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Deranieh RM,Greenberg MLdoi
10.1042/BST0371099subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1099-103issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST0371099journal_volume
37pub_type
杂志文章,评审abstract::From a protein structural viewpoint, tryptophan is often considered an inert structural amino acid, playing a role as a hydrophobic anchor in membrane proteins or as part of the hydrophobic core of soluble proteins. However, tryptophan is the only polyaromatic amino acid and, from a chemical viewpoint, possesses uniqu...
journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2006-11-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2007-12-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2011-10-01 00:00:00
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journal_title:Biochemical Society transactions
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doi:10.1042/BST20130092
更新日期:2013-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2013-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2013-02-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2007-11-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2012-12-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2005-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
abstract::GRIF-1 [GABA(A) (gamma-aminobutyric acid(A)) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail the molecular interaction between GRIF-1 a...
journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2019-02-28 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2019-04-30 00:00:00
abstract::The oxidoreductase Trx-1 (thioredoxin 1) is highly conserved and found intra- and extra-cellularly in mammalian systems. There is increasing interest in its capacity to regulate immune function based on observations of altered distribution and expression during ageing and disease. We have investigated previously wheth...
journal_title:Biochemical Society transactions
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更新日期:2014-08-01 00:00:00