Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?

Abstract:

:Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there are multiple subcellular pools of glucose 6-phosphate. It is proposed that this data can be interpreted in terms of channelling of metabolic intermediates through multiple pathways of glucose metabolism with leakage of glucose 6-phosphate from the channels into a single free pool. It is also proposed that measurement of total tissue content of glucose 6-phosphate approximates the free pool.

journal_name

Biochem Soc Trans

authors

Agius L,Centelles J,Cascante M

doi

10.1042/

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

38-43

issue

2

eissn

0300-5127

issn

1470-8752

journal_volume

30

pub_type

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