Abstract:
:Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there are multiple subcellular pools of glucose 6-phosphate. It is proposed that this data can be interpreted in terms of channelling of metabolic intermediates through multiple pathways of glucose metabolism with leakage of glucose 6-phosphate from the channels into a single free pool. It is also proposed that measurement of total tissue content of glucose 6-phosphate approximates the free pool.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Agius L,Centelles J,Cascante Mdoi
10.1042/keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
38-43issue
2eissn
0300-5127issn
1470-8752journal_volume
30pub_type
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