Abstract:
:The progression of Type 2 diabetes is accompanied by diminishing islet β-cell mass and function. It has been proposed that β-cells are lost not only through apoptosis, but also by dedifferentiating into progenitor-like cells. There is therefore much interest in the mechanisms which define and maintain β-cell identity. The advent of genome-wide analyses of chromatin modifications has highlighted the role of epigenetic factors in determining cell identity. There is also evidence from both human populations and animal models for an epigenetic component in susceptibility to Type 2 diabetes. The mechanisms responsible for defining the epigenetic landscape in individual cell types are poorly understood, but there is growing evidence of a role for lncRNAs (long non-coding RNAs) in this process. In the present paper, we discuss some of the mechanisms through which lncRNAs may contribute to β-cell identity and Type 2 diabetes risk.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Pullen TJ,Rutter GAdoi
10.1042/BST20120355subject
Has Abstractpub_date
2013-06-01 00:00:00pages
797-801issue
3eissn
0300-5127issn
1470-8752pii
BST20120355journal_volume
41pub_type
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