Abstract:
:Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A ( Staphylococcus aureus ) and Protein G ( Streptococcus ). Both of these proteins bind predominantly to the interface of C(H)2-C(H)3 heavy chains, while Protein L binds exclusively to the V(L) domain of the kappa -chain. The function of these proteins in vivo is not clear but it is thought that they enable the bacteria to evade the host's immune system. Two binding sites for kappa -chain on a single Ig-binding domain from Protein L have recently been reported and we give evidence that one site has a 25-55-fold higher affinity for kappa -chain than the second site.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Housden NG,Harrison S,Roberts SE,Beckingham JA,Graille M,Stura E,Gore MGdoi
10.1042/bst0310716keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
716-8issue
Pt 3eissn
0300-5127issn
1470-8752journal_volume
31pub_type
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