Role of AMP-activated protein kinase in the regulation of gene transcription.

Abstract:

:AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.

journal_name

Biochem Soc Trans

authors

Leclerc I,Viollet B,da Silva Xavier G,Kahn A,Rutter GA

doi

10.1042/

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

307-11

issue

2

eissn

0300-5127

issn

1470-8752

journal_volume

30

pub_type

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