mVps34 is activated by an acute bout of resistance exercise.

abstract：:CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug binding, and detection of potential candidates for n...

journal_title：Biochemical Society transactions

authors： Wallace BA,Janes RW

更新日期：2003-06-01 00:00:00

abstract：:Understanding how cognitive processes including learning, memory, decision making and ideation are encoded by the genome is a key question in biology. Identification of sets of genes underlying human mental disorders is a path towards this objective. Schizophrenia is a common disease with cognitive symptoms, high heri...

journal_title：Biochemical Society transactions

authors： Tam GW,van de Lagemaat LN,Redon R,Strathdee KE,Croning MD,Malloy MP,Muir WJ,Pickard BS,Deary IJ,Blackwood DH,Carter NP,Grant SG

更新日期：2010-04-01 00:00:00

abstract：:Extracellular electron transfer has, in one decade, emerged from an environmental phenomenon to an industrial process driver. On the one hand, electron transfer towards anodes leads to production of power or chemicals such as hydrogen, caustic soda and hydrogen peroxide. On the other hand, electron transfer from catho...

journal_title：Biochemical Society transactions

authors： Desloover J,Arends JB,Hennebel T,Rabaey K

更新日期：2012-12-01 00:00:00

abstract：:A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled receptors) has been frustrated by the lack of clear homology between the respective sequences. Here, we review previous computational studies on GPCR dimerization in which the putative dimerization interfaces have been analysed u...

journal_title：Biochemical Society transactions

authors： Vohra S,Chintapalli SV,Illingworth CJ,Reeves PJ,Mullineaux PM,Clark HS,Dean MK,Upton GJ,Reynolds CA

更新日期：2007-08-01 00:00:00

abstract：:The completely sequenced genome of the cyanobacterium Synechocystis PCC 6803 contains several open reading frames, of which the deduced amino acid sequences show similarities to proteins known to be involved in FeS cluster synthesis of nitrogenase (Nif proteins) and other FeS proteins (Isc proteins). In this article, ...

journal_title：Biochemical Society transactions

authors： Seidler A,Jaschkowitz K,Wollenberg M

更新日期：2001-08-01 00:00:00

abstract：:High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a...

journal_title：Biochemical Society transactions

authors： Redman EK,Brookes PS,Karcz MK

更新日期：2013-02-01 00:00:00

abstract：:Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with...

journal_title：Biochemical Society transactions

authors： Pallien T,Klussmann E

更新日期：2020-02-28 00:00:00

abstract：:Our first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated with reactivation of herpes simplex virus; his erythematous eruptions could be controlled with infusions of fresh frozen plasma containing MBL, but not with plasma lacking MB...

journal_title：Biochemical Society transactions

authors： Valdimarsson H

更新日期：2003-08-01 00:00:00

abstract：:The human RAD30B gene has recently been shown to encode a novel DNA polymerase, DNA polymerase iota (poliota). The role of poliota within the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterization in vitro. The aim of this short review is, therefore, to summar...

journal_title：Biochemical Society transactions

authors： Tissier A,Frank EG,McDonald JP,Vaisman A,Fernàndez de Henestrosa AR,Boudsocq F,McLenigan MP,Woodgate R

更新日期：2001-05-01 00:00:00

abstract：:CoA (coenzyme A) is a ubiquitous and essential cofactor that acts as an acyl group carrier in biochemical reactions. Apart from participating in numerous metabolic pathways as substrates and intermediates, CoA and a number of its thioester derivatives, such as acetyl-CoA, can also directly regulate the activity of pro...

journal_title：Biochemical Society transactions

authors： Tsuchiya Y,Pham U,Gout I

更新日期：2014-08-01 00:00:00

abstract：:Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse grou...

journal_title：Biochemical Society transactions

authors： Chivet M,Javalet C,Hemming F,Pernet-Gallay K,Laulagnier K,Fraboulet S,Sadoul R

更新日期：2013-02-01 00:00:00

abstract：:Regulation of protein synthesis is an important aspect of growth control. RNA polymerase (pol) III plays a key role in this process by catalysing production of tRNA and 5 S rRNA. Growth factors trigger a rapid increase in pol III activity and this is essential for cell proliferation. The transcription factor TFIIIB pl...

journal_title：Biochemical Society transactions

authors： Mauger E,Scott PH

更新日期：2004-12-01 00:00:00

abstract：:Phosphorus is one of the most important macronutrients and is indispensable for all organisms as a critical structural component as well as participating in intracellular signalling and energy metabolism. Sensing and signalling of phosphate (Pi) has been extensively studied and is well understood in single-cellular or...

journal_title：Biochemical Society transactions

authors： Qi W,Baldwin SA,Muench SP,Baker A

更新日期：2016-06-15 00:00:00

abstract：:Activated tyrosine kinase receptors acquire ubiquitin tags. Ubiquitination governs receptor down-regulation through interaction with components of the endosomal ESCRT (endosomal sorting complexes required for transport) machinery that shepherds receptors into luminal vesicles of multivesicular bodies en route to the l...

journal_title：Biochemical Society transactions

authors： Urbé S,McCullough J,Row P,Prior IA,Welchman R,Clague MJ

更新日期：2006-11-01 00:00:00

abstract：:Whereas we have a profound understanding about the function and biogenesis of the protein constituents in the lumen of the lysosomal compartment, much less is known about the functions of proteins of the lysosomal membrane. Proteomic analyses of the lysosomal membrane suggest that, apart from the well-known lysosomal ...

journal_title：Biochemical Society transactions

authors： Saftig P,Schröder B,Blanz J

更新日期：2010-12-01 00:00:00

abstract：:African trypanosomes have plastic genomes with extensive variability at the chromosome ends. The genes encoding the expressed major surface protein of the infective bloodstream form stages of Trypanosoma brucei and are located at telomeres. These telomeric expression-site transcription units are turning out to be surp...

journal_title：Biochemical Society transactions

authors： Rudenko G

更新日期：2000-10-01 00:00:00

abstract：:cAMP is an essential signalling molecule whose concentration in cells is regulated by a wide range of hormones. A large number of diseases, including cancer and asthma, are linked to improper regulation of the cAMP signalling system, and manipulation of cAMP levels by pharmaceutical agents has proven therapeutic benef...

journal_title：Biochemical Society transactions

authors： Yarwood SJ

更新日期：2005-12-01 00:00:00

abstract：:The human colonic microbiota degrades dietary substrates that are indigestible in the upper GIT (gastrointestinal tract), releasing bacterial metabolites, some of which are important for gut health. Advances in molecular biology techniques have facilitated detailed analyses of the composition of the bacterial communit...

journal_title：Biochemical Society transactions

authors： Scott KP,Duncan SH,Louis P,Flint HJ

更新日期：2011-08-01 00:00:00

abstract：:Mice devoid of the original uncoupling protein UCP1 have provided opportunities to delineate UCP1 function in a series of biochemical and physiological contexts. The isolated brown-fat mitochondria from such mice are fully coupled (without the addition of GDP), but still exhibit a depressed capacity for ATP synthesis....

journal_title：Biochemical Society transactions

authors： Nedergaard J,Golozoubova V,Matthias A,Shabalina I,Ohba K,Ohlson K,Jacobsson A,Cannon B

更新日期：2001-11-01 00:00:00

abstract：:The availability of entire genome sequences and the wealth of literature on gene regulation have enabled researchers to model an organism's transcriptional regulation system in the form of a network. In such a network, TFs (transcription factors) and TGs (target genes) are represented as nodes and regulatory interacti...

journal_title：Biochemical Society transactions

authors： Babu MM

更新日期：2010-10-01 00:00:00

abstract：:Plant chloroplasts contain an intricate photosynthetic membrane system, the thylakoids, and are surrounded by two envelope membranes at which thylakoid lipids are assembled. The glycoglycerolipids mono- and digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol as well as phosphatidylglycerol, are present in th...

journal_title：Biochemical Society transactions

authors： Wang Z,Benning C

更新日期：2012-04-01 00:00:00

abstract：:Whereas spontaneous point mutation operates on nucleotides individually, sexual recombination manipulates the set of nucleotides within an allele as an essentially particulate unit. In principle, these two different scales of variation enable selection to follow fitness gradients in two different spaces: in nucleotide...

journal_title：Biochemical Society transactions

authors： Watson RA,Weinreich DM,Wakeley J

更新日期：2006-08-01 00:00:00

abstract：:In the present article, I discuss recent developments in the naming of the TOR (target of rapamycin) protein. In particular, I address the issue of mammalian target of rapamycin (mTOR) versus the newer mechanistic target of rapamycin (MTOR). mTOR is the name given by the TOR community almost two decades ago and widely...

journal_title：Biochemical Society transactions

authors： Hall MN

更新日期：2013-08-01 00:00:00

abstract：:Nucleosomes are actively positioned along DNA by ATP-dependent, chromatin remodelling factors. A structural model for the ISW1a chromatin remodelling factor from Saccharomyces cerevisiae in complex with a dinucleosome substrate was constructed from the X-ray structures of ISW1a (ΔATPase) with and without DNA bound, tw...

journal_title：Biochemical Society transactions

authors： Richmond TJ

更新日期：2012-04-01 00:00:00

abstract：:A number of studies demonstrate disturbances of the central innate immune system in AD (Alzheimer's disease). In animal and human studies, there is evidence of close communication between systemic and central innate immune systems. Animal models of neurodegeneration show evidence of an exaggerated central innate immun...

journal_title：Biochemical Society transactions

authors： Holmes C,Butchart J

更新日期：2011-08-01 00:00:00

abstract：:Insect and mammalian circadian clocks show striking similarities. They utilize homologous clock genes, generating self-sustained circadian oscillations in distinct master clocks of the brain, which then control rhythmic behaviour. The molecular mechanisms of rhythm generation were first uncovered in the fruit fly Dros...

journal_title：Biochemical Society transactions

authors： Helfrich-Förster C

更新日期：2005-11-01 00:00:00

abstract：:14-3-3 proteins are involved in signalling processes in neuronal cells. Using isoform-specific antibodies we have examined the variation in 14-3-3 isoform neurolocation in normal and scrapie-infected murine brain and show that in defined areas of the brain there are significant changes associated with the pathology of...

journal_title：Biochemical Society transactions

authors： Baxter HC,Fraser JR,Liu WG,Forster JL,Clokie S,Steinacker P,Otto M,Bahn E,Wiltfang J,Aitken A

更新日期：2002-08-01 00:00:00

abstract：:Structure-based design has gained credibility as a valuable component of the modern drug discovery process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR for providing structural features of drug ...

journal_title：Biochemical Society transactions

authors： Middleton DA

更新日期：2007-11-01 00:00:00

abstract：:Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration...

journal_title：Biochemical Society transactions

authors： Meaburn KJ,Levy N,Toniolo D,Bridger JM

更新日期：2005-12-01 00:00:00

abstract：:Genetic experiments have established an important role for the ubiquitin-like molecule NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) in the regulation of cell growth, viability and development. It is therefore essential to identify the molecular targets for the pathway. Until recently, the c...

journal_title：Biochemical Society transactions

authors： Xirodimas DP

更新日期：2008-10-01 00:00:00