Abstract：
:Whereas we have a profound understanding about the function and biogenesis of the protein constituents in the lumen of the lysosomal compartment, much less is known about the functions of proteins of the lysosomal membrane. Proteomic analyses of the lysosomal membrane suggest that, apart from the well-known lysosomal membrane proteins, additional and less abundant membrane proteins are present. The identification of disease-causing genes and the in-depth analysis of knockout mice leading to mutated or absent membrane proteins of the lysosomal membrane have demonstrated the essential role of these proteins in lysosomal acidification, transport of metabolites resulting from hydrolytic degradation and interaction and fusion with other cellular membrane systems. In addition, trafficking pathways of lysosomal membrane proteins are closely linked to the biogenesis of this compartment. This is exemplified by the recent finding that LIMP-2 (lysosomal integral membrane protein type-2) is responsible for the mannose 6-phosphate receptor-independent delivery of newly synthesized β-glucocerebrosidase to the lysosome. Similar to LIMP-2, which could also be linked to vesicular transport processes in certain polarized cell types, the major constituents of the lysosomal membrane, the glycoproteins LAMP (lysosome-associated membrane protein)-1 and LAMP-2 are essential for regulation of lysosomal motility and participating in control of membrane fusion events between autophagosomes or phagosomes with late endosomes/lysosomes. Our recent investigations into the role of these proteins have not only increased our understanding of the endolysosomal system, but also supported their major role in cell physiology and the development of different diseases.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Saftig P,Schröder B,Blanz Jdoi
10.1042/BST0381420subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1420-3issue
6eissn
0300-5127issn
1470-8752pii
BST0381420journal_volume
38pub_type
杂志文章abstract：:Here, we describe a recently discovered O-GlcNAc transferase termed EOGT for EGF domain-specific O-GlcNAc transferase. EOGT transfers GlcNAc (N-acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor-like repeats with a specific consensus sequence. Thus, EOGT...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20160165
更新日期：2017-04-15 00:00:00
abstract：:Ribonucleic acids are driving a multitude of biological processes where they act alone or in complex with proteins (ribonucleoproteins, RNP). To understand these processes both structural and mechanistic information about RNA is necessary. Due to their conformational plasticity RNA pose a challenge for mainstream stru...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20191080
更新日期：2020-06-30 00:00:00
abstract：:Single-molecule fluorescence methods, particularly single-molecule FRET (fluorescence resonance energy transfer), have provided novel insights into the structure, interactions and dynamics of biological systems. ALEX (alternating-laser excitation) spectroscopy is a new method that extends single-molecule FRET by provi...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0360738
更新日期：2008-08-01 00:00:00
abstract：:JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that the removal of specific Jnk genes can reduce neuronal death ass...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20110641
更新日期：2012-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20120088
更新日期：2012-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2002-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0311062
更新日期：2003-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20140183
更新日期：2014-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0381037
更新日期：2010-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20110708
更新日期：2011-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0361277
更新日期：2008-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0340837
更新日期：2006-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20120026
更新日期：2012-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0391149
更新日期：2011-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/
更新日期：2002-04-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20110657
更新日期：2011-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0350508
更新日期：2007-06-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0371378
更新日期：2009-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:Identified five decades ago amongst the most abundant cellular RNAs, small nucleolar RNAs (snoRNAs) were initially described as serving as guides for the methylation and pseudouridylation of ribosomal RNA through direct base pairing. In recent years, however, increasingly powerful high-throughput genomic approaches an...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20191046
更新日期：2020-04-29 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20120111
更新日期：2012-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0320766
更新日期：2004-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20160396
更新日期：2017-02-08 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theore...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20051154
更新日期：2005-11-01 00:00:00
abstract：:Luteinizing hormone (LH) interacts with its plasma membrane receptor to activate the formation of cyclic AMP via the regulatory GTP binding protein (Gs). This is followed by a desensitization of that same hormonal response which is caused by an uncoupling of the LH receptor from Gs. The coupling between Gs and the ade...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0170633
更新日期：1989-08-01 00:00:00
abstract：:A limited number of bacteria, yeast and fungi can convert hemicellulose or its monomers (xylose, arabinose, mannose and galactose) into ethanol with a satisfactory yield and productivity. In the present study we tested a number of thermophilic enrichment cultures, and new isolates of thermophilic anaerobic bacterial s...
journal_title：Biochemical Society transactions
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doi：10.1042/bst0320283
更新日期：2004-04-01 00:00:00
abstract：:Intracellular pathogens survive in eukaryotic cells by evading a variety of host defences. To avoid degradation through the endocytic pathway, intracellular bacteria must adapt their phagosomes into protective compartments that promote bacterial replication. Legionella pneumophila and Coxiella burnetii are Gram-negati...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20120167
更新日期：2012-12-01 00:00:00
abstract：:Quinone oxidoreductases are a class of membrane enzymes that catalyse the oxidation or reduction of membrane-bound quinols/quinones. The conversion of quinone/quinol by these enzymes is difficult to study because of the hydrophobic nature of the enzymes and their substrates. We describe some biochemical properties of ...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0370707
更新日期：2009-08-01 00:00:00
abstract：:Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0380879
更新日期：2010-08-01 00:00:00
