Abstract:
:Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration and premature aging have been linked with mutations in lamin A or emerin. These are termed laminopathies, with mutations in emerin causing Emery-Dreifuss muscular dystrophy. Despite highly aberrant nuclear distributions of A-type lamins and emerin in lymphoblastoid cell lines derived from patients with emerin or lamin A mutations, little or no change in chromosome location was detected.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Meaburn KJ,Levy N,Toniolo D,Bridger JMdoi
10.1042/BST20051438keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1438-40issue
Pt 6eissn
0300-5127issn
1470-8752pii
BST20051438journal_volume
33pub_type
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