Tetraspanins in the humoral immune response.

abstract：:Cell-free transcription-translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical test kits for on-site identification of viruses (Zika and Ebola), while gene...

journal_title：Biochemical Society transactions

authors： Moore SJ,MacDonald JT,Freemont PS

更新日期：2017-06-15 00:00:00

abstract：:A new method of monitoring the rate of reactions in solid-phase peptide synthesis is described. A conductivity detector in the reaction cell (patent applied for) enables the deprotection, washing and subsequent coupling stages to be examined in detail. The half-lives of the reactions can be calculated and hence the op...

journal_title：Biochemical Society transactions

authors： Fox JE

更新日期：1990-12-01 00:00:00

abstract：:It is now clear that NSPs (neutrophil serine proteases), including elastase, Pr3 (proteinase 3) and CatG (cathepsin G) are major pathogenic determinants in chronic inflammatory disorders of the lungs. Two unglycosylated natural protease inhibitors, SLPI (secretory leucocyte protease inhibitor) and elafin, and its prec...

journal_title：Biochemical Society transactions

authors： Zani ML,Tanga A,Saidi A,Serrano H,Dallet-Choisy S,Baranger K,Moreau T

更新日期：2011-10-01 00:00:00

abstract：:Nitrogenase activity in Rhodospirillum rubrum is post-translationally regulated by DRAG (dinitrogenase reductase glycohydrolase) and DRAT (dinitrogenase reductase ADP-ribosylation transferase). When a sudden increase in fixed nitrogen concentration or energy depletion is sensed by the cells, DRAG is inactivated and DR...

journal_title：Biochemical Society transactions

authors： Wang H,Norén A

更新日期：2006-02-01 00:00:00

abstract：:Horses and other equids are unusual in producing protein-rich sweat for thermoregulation, a major component of which is latherin, a highly surface-active, non-glycosylated protein that is a member of the PLUNC (palate, lung and nasal epithelium clone) family. Latherin produces a significant reduction in water surface ...

journal_title：Biochemical Society transactions

authors： Kennedy MW

更新日期：2011-08-01 00:00:00

abstract：:Polycomb group (PcG) proteins are highly conserved chromatin-modifying complexes that implement gene silencing in higher eukaryotes. Thousands of genes and multiple developmental processes are regulated by PcG proteins. As the first chromatin modifier been identified in model plant Arabidopsis thaliana, the methyltran...

journal_title：Biochemical Society transactions

authors： Jiao H,Xie Y,Li Z

更新日期：2020-08-28 00:00:00

abstract：:Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cel...

journal_title：Biochemical Society transactions

authors： Scott JD

更新日期：2003-02-01 00:00:00

abstract：:Non-coding transcripts play an important role in gene expression regulation in all species, including budding and fission yeast. Such regulatory transcripts include intergenic ncRNA (non-coding RNA), 5' and 3' UTRs, introns and antisense transcripts. In the present review, we discuss advantages and limitations of rece...

journal_title：Biochemical Society transactions

authors： Schlackow M,Gullerova M

更新日期：2013-12-01 00:00:00

abstract：:Saccharomyces cerevisiae cells grown in glucose have larger average size than cells grown in ethanol. Besides, yeast must reach a carbon source-modulated critical cell size in order to enter S phase at Start. This control is of outmost physiological relevance, since it allows us to coordinate cell growth with cell cyc...

journal_title：Biochemical Society transactions

authors： Vanoni M,Rossi RL,Querin L,Zinzalla V,Alberghina L

更新日期：2005-02-01 00:00:00

abstract：:The neurotrophins nerve growth factor, brain-derived neurotrophic factor, NT-3 (neurotrophin 3) and NT-4 are known for regulating neuron development, function and survival. Beyond this, neurotrophins were found to exert multiple effects on non-neuronal cells such as immune cells, smooth muscle and epithelial cells. In...

journal_title：Biochemical Society transactions

authors： Rochlitzer S,Nassenstein C,Braun A

更新日期：2006-08-01 00:00:00

abstract：:Post-transcriptional gene silencing (PTGS) has been successfully used to modify seed lipids in oilseed crops like soybean, canola and sunflower. Conventionally, PTGS has been induced by transforming the plants with either antisense or co-suppression constructs targeted against key seed lipid biosynthesis genes. A majo...

journal_title：Biochemical Society transactions

authors： Singh S,Green A,Stoutjesdijk P,Liu Q

更新日期：2000-12-01 00:00:00

abstract：:FcRn was originally identified as the receptor responsible for IgG binding to the intestinal epithelium of neonatal rats and mice. FcRn transports IgG from milk across the intestinal epithelial cells of the suckling animal. Subsequently, FcRn was detected in tissues involved in the transmission of IgG from mother to f...

journal_title：Biochemical Society transactions

authors： Simister NE,Jacobowitz Israel E,Ahouse JC,Story CM

更新日期：1997-05-01 00:00:00

abstract：:During early flower development in Arabidopsis, floral stem cells proliferate and produce a sufficient amount of cells that are recruited for organogenesis. However, after the central organ primordia initiate, stem cell activity in the floral meristem is terminated to ensure the differentiation of a fixed number of fl...

journal_title：Biochemical Society transactions

authors： Sun B,Ito T

更新日期：2010-04-01 00:00:00

abstract：:Ribonucleic acids are driving a multitude of biological processes where they act alone or in complex with proteins (ribonucleoproteins, RNP). To understand these processes both structural and mechanistic information about RNA is necessary. Due to their conformational plasticity RNA pose a challenge for mainstream stru...

journal_title：Biochemical Society transactions

authors： Sreemantula AK,Marchanka A

更新日期：2020-06-30 00:00:00

abstract：:Identified five decades ago amongst the most abundant cellular RNAs, small nucleolar RNAs (snoRNAs) were initially described as serving as guides for the methylation and pseudouridylation of ribosomal RNA through direct base pairing. In recent years, however, increasingly powerful high-throughput genomic approaches an...

journal_title：Biochemical Society transactions

authors： Bergeron D,Fafard-Couture É,Scott MS

更新日期：2020-04-29 00:00:00

abstract：:Phosphorus is one of the most important macronutrients and is indispensable for all organisms as a critical structural component as well as participating in intracellular signalling and energy metabolism. Sensing and signalling of phosphate (Pi) has been extensively studied and is well understood in single-cellular or...

journal_title：Biochemical Society transactions

authors： Qi W,Baldwin SA,Muench SP,Baker A

更新日期：2016-06-15 00:00:00

abstract：:Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might be utilised as diagnostic and therapeutic tools. There remain, ...

journal_title：Biochemical Society transactions

authors： Clemmens H,Lambert DW

更新日期：2018-10-19 00:00:00

abstract：:Large amounts of DNA are frequently required for use in detection assays and genomic analysis. The limited availability of DNA can be a critical obstacle to meeting research and clinical needs. DNA amplification methods are often required to generate sufficient material from small specimens or environmental samples wi...

journal_title：Biochemical Society transactions

authors： Lasken RS

更新日期：2009-04-01 00:00:00

abstract：:Membrane proteins are drug targets for a wide range of diseases. Having access to appropriate samples for further research underpins the pharmaceutical industry's strategy for developing new drugs. This is typically achieved by synthesizing a protein of interest in host cells that can be cultured on a large scale, all...

journal_title：Biochemical Society transactions

authors： Bawa Z,Bland CE,Bonander N,Bora N,Cartwright SP,Clare M,Conner MT,Darby RA,Dilworth MV,Holmes WJ,Jamshad M,Routledge SJ,Gross SR,Bill RM

更新日期：2011-06-01 00:00:00

abstract：:Data from experimental studies in animals and from epidemiological studies in humans suggest a link between insulin and cognitive performance. Do these results translate into clinical and therapeutic benefit for people with cognitive impairment? Insulin injected peripherally can readily cross the blood-brain barrier. ...

journal_title：Biochemical Society transactions

authors： Strachan MW

更新日期：2005-11-01 00:00:00

abstract：:CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations and (ii) it avoids creating DNA double-strand breaks, which can lead to unintended chromosomal alterations or elicit an unwanted DNA damage response. Given many cancers originate from poin...

journal_title：Biochemical Society transactions

authors： Pal M,Herold MJ

更新日期：2021-01-15 00:00:00

abstract：:Many Zn(II)2Cys6 transcriptional regulators exhibit changes in phosphorylation that are coincident with their roles in transcriptional activation. It is, however, unclear whether these changes occur as a cause of, or as a result of, transcriptional activation. In this paper, we explore the relationship between these t...

journal_title：Biochemical Society transactions

authors： Leverentz MK,Reece RJ

更新日期：2006-11-01 00:00:00

abstract：:Ligand-gated ion channels function as rapid signal transducers, converting chemical signals (in the form of neurotransmitters) into electrical signals in the postsynaptic neuron. This is achieved by the recognition of neurotransmitter at its specific-binding sites, which then triggers the opening of an ion channel ('g...

journal_title：Biochemical Society transactions

authors： Kash TL,Trudell JR,Harrison NL

更新日期：2004-06-01 00:00:00

abstract：:A comparative approach has been used to study the role of several lipid-body-binding proteins in plants and animals. Caleosins are a newly discovered class of calcium-binding lipid-body proteins found in plants and fungi, which we now report to have separate endoplasmic reticulum- and lipid-body-associated isoforms. W...

journal_title：Biochemical Society transactions

authors： Murphy DJ,Hernendez-Pinzon I,Patel K,Hope RG,McLauchlan J

更新日期：2000-12-01 00:00:00

abstract：:Animal venoms are recognised as unique biological systems in which to study molecular evolution. Venom use has evolved numerous times among the insects, and insects today use venom to capture prey, defend themselves from predators, or to subdue and modulate host responses during parasitism. However, little is known ab...

journal_title：Biochemical Society transactions

authors： Walker AA

更新日期：2020-08-28 00:00:00

abstract：:Reactive oxygen species (ROS) were originally thought to only be released by phagocytic cells during their role in host defence. It is now clear that ROS have a cell signalling role in many biological systems, both in animals and in plants. ROS induce programmed cell death or necrosis, induce or suppress the expressio...

journal_title：Biochemical Society transactions

authors： Hancock JT,Desikan R,Neill SJ

更新日期：2001-05-01 00:00:00

abstract：:The 'fusion peptides' of a group of enveloped viruses that includes influenza, paramyxo-, retro-and filo-viruses are N-terminal regions of their membrane fusion proteins generated by cleavage of non-functional precursors. For the influenza membrane fusion protein, haemagglutinin (HA), the three-dimensional structures ...

journal_title：Biochemical Society transactions

authors： Skehel JJ,Cross K,Steinhauer D,Wiley DC

更新日期：2001-08-01 00:00:00

abstract：:The central role of VEGF (vascular endothelial growth factor A) in angiogenesis is dependent upon its ability to co-ordinately regulate multiple endothelial functions. The multifunctionality of VEGF at the cellular level results from its ability to initiate a diverse, complex and integrated network of signalling pathw...

journal_title：Biochemical Society transactions

authors： Zachary I

更新日期：2003-12-01 00:00:00

abstract：:Functional cardiomyocytes can now be derived routinely from hPSCs (human pluripotent stem cells), which collectively include embryonic and induced pluripotent stem cells. This technology presents new opportunities to develop pharmacologically relevant in vitro screens to detect cardiotoxicity, with a view to improving...

journal_title：Biochemical Society transactions

authors： Dick E,Rajamohan D,Ronksley J,Denning C

更新日期：2010-08-01 00:00:00

abstract：:AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Once activated by falling cellular energy levels, it acts to restore energy homoeostasis by switching on catabolic pathways that generate ATP, while switching off anabolic pathwa...

journal_title：Biochemical Society transactions

authors： Gowans GJ,Hardie DG

更新日期：2014-02-01 00:00:00