Abstract:
:Zebrafish (Danio rerio) are becoming an increasingly powerful model organism to study the role of metabolism in disease. Since its inception, the zebrafish model has relied on unique attributes such as the transparency of embryos, high fecundity and conservation with higher vertebrates, to perform phenotype-driven chemical and genetic screens. In this review, we describe how zebrafish have been used to reveal novel mechanisms by which metabolism regulates embryonic development, obesity, fatty liver disease and cancer. In addition, we will highlight how new approaches in advanced microscopy, transcriptomics and metabolomics using zebrafish as a model system have yielded fundamental insights into the mechanistic underpinnings of disease.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Salmi TM,Tan VWT,Cox AGdoi
10.1042/BST20180335subject
Has Abstractpub_date
2019-02-28 00:00:00pages
305-315issue
1eissn
0300-5127issn
1470-8752pii
BST20180335journal_volume
47pub_type
杂志文章,评审abstract::Effective stroke therapies require recanalization of occluded cerebral blood vessels; however, early reperfusion can cause BBB (blood-brain barrier) injury, leading to cerebral oedema and/or devastating brain haemorrhage. These complications of early reperfusion, which result from excess production of ROS (reactive ox...
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更新日期:2020-06-30 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:
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journal_title:Biochemical Society transactions
pub_type: 历史文章,杂志文章,评审
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2002-08-01 00:00:00
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journal_title:Biochemical Society transactions
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pub_type: 杂志文章,评审
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2019-02-28 00:00:00
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更新日期:2020-10-30 00:00:00