Seasonal variations of diacylglyceryl-N,N,N-trimethylhomoserine content in Polypodiophyta.

abstract：:Enzymes of the 1-deoxy-D-xylulose 5-phosphate/2-C-methylerythritol 4-phosphate (DOXP/MEP) pathway are targets for new herbicides and antibacterial drugs. Until now, no inhibitors for the DOXP synthase have been known of. We show that one of the breakdown products of the herbicide clomazone affects the DOXP synthase. O...

journal_title：Biochemical Society transactions

authors： Mueller C,Schwender J,Zeidler J,Lichtenthaler HK

更新日期：2000-12-01 00:00:00

abstract：:The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases...

journal_title：Biochemical Society transactions

authors： Krapp A,Simanis V

更新日期：2008-06-01 00:00:00

abstract：:Vibrational changes in the catalytic site of horseradish peroxidase were investigated by FTIR (Fourier-transform infrared) spectroscopy in the 1000-2500 cm(-1) range. Difference spectra were generated by photolysis of the haemII-CO compound at different pH/pD values. The spectra report on the fine structure around the...

journal_title：Biochemical Society transactions

authors： Ingledew WJ,Rich PR

更新日期：2005-08-01 00:00:00

abstract：:PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP produc...

journal_title：Biochemical Society transactions

authors： Aerts L,De Strooper B,Morais VA

更新日期：2015-04-01 00:00:00

abstract：:In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates...

journal_title：Biochemical Society transactions

authors： Gnaiger E,Kuznetsov AV

更新日期：2002-04-01 00:00:00

abstract：:Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...

journal_title：Biochemical Society transactions

authors： Matsumoto S,Masai H

更新日期：2013-12-01 00:00:00

abstract：:The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. This receptor complex allows for integrated signalling in response to growth fact...

journal_title：Biochemical Society transactions

authors： Pyne NJ,Waters C,Moughal NA,Sambi BS,Pyne S

更新日期：2003-12-01 00:00:00

abstract：:With >800 members, G protein-coupled receptors (GPCRs) are the largest class of cell-surface signalling proteins, and their activation mediates diverse physiological processes. GPCRs are ubiquitously distributed across all cell types, involved in many diseases and are major drug targets. However, GPCR drug discovery i...

journal_title：Biochemical Society transactions

authors： Ellisdon AM,Halls ML

更新日期：2016-04-15 00:00:00

abstract：:Copper chaperones, soluble copper-binding proteins, are essential for ensuring proper distribution of copper to cellular compartments and to proteins requiring copper prosthetic groups. They are found in all eukaryotic organisms. Orthologues of the three copper chaperones characterized in yeast, ATX1, CCS and COX17, a...

journal_title：Biochemical Society transactions

authors： Wintz H,Vulpe C

更新日期：2002-08-01 00:00:00

abstract：:The energy-converting NADH:ubiquinone oxidoreductase, also known as respiratory complex I, couples the transfer of electrons from NADH to ubiquinone with the translocation of ions across the membrane. It was assumed that the complex exclusively works as a proton pump. Recently, it has been proposed that complex I from...

journal_title：Biochemical Society transactions

authors： Friedrich T,Stolpe S,Schneider D,Barquera B,Hellwig P

更新日期：2005-08-01 00:00:00

abstract：:The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is conver...

journal_title：Biochemical Society transactions

authors： Mori K

更新日期：2003-02-01 00:00:00

abstract：:Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to av...

journal_title：Biochemical Society transactions

authors： Smith LM,May RC

更新日期：2013-04-01 00:00:00

abstract：:In plant and metazoan, Polycomb Group (PcG) proteins play key roles in regulating developmental processes by repression of gene expression. PcG proteins function as multi-protein complexes; among them the best characterized ones are Polycomb Repressive Complex 1 (PRC1) and PRC2. PRC2 catalyzes histone H3 lysine 27 tri...

journal_title：Biochemical Society transactions

authors： Wang Q,Shen WH

更新日期：2018-08-20 00:00:00

abstract：:The cytochromes P450 (P450s) are a superfamily of oxidative haemoproteins that are capable of catalysing a vast range of oxidative transformations, including the oxidation of unactivated alkanes, often with high stereo- and regio-selectivity. Fatty acid hydroxylation by P450s is widespread across both bacteria and hig...

journal_title：Biochemical Society transactions

authors： Cryle MJ

更新日期：2010-08-01 00:00:00

abstract：:Evidence indicates that leucine-rich repeat kinase 2 (LRRK2) controls multiple processes in neurons and glia cells. Deregulated LRRK2 activity due to gene mutation represents the most common cause of autosomal dominant Parkinson's disease (PD). Protein kinase A (PKA)-mediated signaling is a key regulator of brain func...

journal_title：Biochemical Society transactions

authors： Greggio E,Bubacco L,Russo I

更新日期：2017-02-08 00:00:00

abstract：:Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis. The patients were diagnosed in adulthood with CN...

journal_title：Biochemical Society transactions

authors： Texel SJ,Xu X,Harris ZL

更新日期：2008-12-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H(+)-PPase or VP1), the vacuolar proton ATPase (V-H(+)-ATPase) or both, maintain their acidity. A vacuolar transporter ch...

journal_title：Biochemical Society transactions

authors： Lander N,Cordeiro C,Huang G,Docampo R

更新日期：2016-02-01 00:00:00

abstract：:Peptide-bond formation is the enzymatic activity of the ribosome. The catalytic site is made up of ribosomal RNA, indicating that the ribosome is a ribozyme. This review summarizes the recent progress in understanding the mechanism of peptide bond formation. The results of biochemical and kinetic experiments, mutagene...

journal_title：Biochemical Society transactions

authors： Rodnina MV,Beringer M,Bieling P

更新日期：2005-06-01 00:00:00

abstract：:The avascular nature of the human intervertebral disc is thought to reduce the ability of resident disc cells to maintain their extracellular matrix, rendering the tissue susceptible to degeneration. It has also been suggested that the lack of a blood supply may result in disc cell death via nutrient deprivation. Ther...

journal_title：Biochemical Society transactions

authors： Johnson WE,Roberts S

更新日期：2007-08-01 00:00:00

abstract：:A considerable number of fungal homologues of human apoptotic genes have been identified in recent years. Nevertheless, we are far from being able to connect the different pieces and construct a primary structure of the fungal apoptotic regulatory network. To get a better picture of the available fungal components, we...

journal_title：Biochemical Society transactions

authors： Shlezinger N,Doron A,Sharon A

更新日期：2011-10-01 00:00:00

abstract：:The thermoacidophile crenarchaeote Sulfolobus ssp. is one of the best-studied Archaea. Cryptic and conjugative plasmids as well as viruses have been described for this genus. For the majority of the genetic elements only the genome sequence and the basic characteristics were determined. In contrast the fusellovirus SS...

journal_title：Biochemical Society transactions

authors： Lipps G

更新日期：2004-04-01 00:00:00

abstract：:The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned s...

journal_title：Biochemical Society transactions

authors： Carmena M

更新日期：2008-06-01 00:00:00

abstract：:Sister-chromatid cohesion, thought to be primarily mediated by the cohesin complex, is essential for chromosome segregation. The forces holding the two sisters resist the tendency of microtubules to prematurely pull sister DNAs apart and thereby prevent random segregation of the genome during mitosis, and consequent a...

journal_title：Biochemical Society transactions

authors： Oliveira RA,Nasmyth K

更新日期：2010-12-01 00:00:00

abstract：:Mice devoid of the original uncoupling protein UCP1 have provided opportunities to delineate UCP1 function in a series of biochemical and physiological contexts. The isolated brown-fat mitochondria from such mice are fully coupled (without the addition of GDP), but still exhibit a depressed capacity for ATP synthesis....

journal_title：Biochemical Society transactions

authors： Nedergaard J,Golozoubova V,Matthias A,Shabalina I,Ohba K,Ohlson K,Jacobsson A,Cannon B

更新日期：2001-11-01 00:00:00

abstract：:Biological diversity in marine OMZs (oxygen minimum zones) is dominated by a complex community of bacteria and archaea whose anaerobic metabolisms mediate key steps in global nitrogen and carbon cycles. Molecular and physiological studies now confirm that OMZs also support diverse micro-organisms capable of utilizing ...

journal_title：Biochemical Society transactions

authors： Stewart FJ

更新日期：2011-12-01 00:00:00

abstract：:The tetraspanins represent a large superfamily of four-transmembrane proteins that are expressed on all nucleated cells. Tetraspanins play a prominent role in the organization of the plasma membrane by co-ordinating the spatial localization of transmembrane proteins and signalling molecules into 'tetraspanin microdoma...

journal_title：Biochemical Society transactions

authors： van Spriel AB

更新日期：2011-04-01 00:00:00

abstract：:As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease. As such, memapsin 2 is an excellent target of inhibitor drugs for the treatment of this disease. Here we describe the tools for memapsin 2 inhibitor design that have been developed and resu...

journal_title：Biochemical Society transactions

authors： Hong L,Turner RT 3rd,Koelsch G,Ghosh AK,Tang J

更新日期：2002-08-01 00:00:00

abstract：:Many quinone-reactive enzyme complexes that are part of membrane-integral eukaryotic or prokaryotic respiratory electron transport chains contain one or more haem b molecules embedded in the membrane. In recent years, various novel proteins have emerged that are devoid of haem b but are thought to fulfil a similar fun...

journal_title：Biochemical Society transactions

authors： Simon J,Kern M

更新日期：2008-10-01 00:00:00

abstract：:The network of the ER (endoplasmic reticulum) is set up by cytoskeletal control of the movement and remodelling of polygonal rings of tubules, bundles of tubules and cisternal regions. We have developed a new image analysis tool, persistency mapping, to understand the framework upon which the plant ER remodels. With t...

journal_title：Biochemical Society transactions

authors： Griffing LR

更新日期：2010-06-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD) with autosomal dominant inheritance. Accordingly, LRRK2 has emerged as a promising therapeutic target for disease modification in PD. Since the first discovery of LRRK2 mutations some 12 years ago,...

journal_title：Biochemical Society transactions

authors： Islam MS,Moore DJ

更新日期：2017-02-08 00:00:00