Abstract:
:Enzymes of the 1-deoxy-D-xylulose 5-phosphate/2-C-methylerythritol 4-phosphate (DOXP/MEP) pathway are targets for new herbicides and antibacterial drugs. Until now, no inhibitors for the DOXP synthase have been known of. We show that one of the breakdown products of the herbicide clomazone affects the DOXP synthase. One inhibitor of the non-mevalonate pathway, fosmidomycin, blocks the DOXP reductoisomerase (DXR) of plants and bacteria. The I(50) values of plants are, however, higher than those found for the DXR of Escherichia coli. The DXR of plants, isolated from barley seedlings, shows a pH optimum of 8.1, which is typical for enzymes active in the chloroplast stroma.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Mueller C,Schwender J,Zeidler J,Lichtenthaler HKkeywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
792-3issue
6eissn
0300-5127issn
1470-8752journal_volume
28pub_type
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