Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.

abstract：:The Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. In addition, it is the main target for a Chk1 (checkpoint kinase 1)-dependent Cdc25/CDK2 (cyclin-dependent kinase 2)-independent DNA damage checkpoint signal ...

journal_title：Biochemical Society transactions

authors： Broderick R,Nasheuer HP

更新日期：2009-08-01 00:00:00

abstract：:Data from experimental studies in animals and from epidemiological studies in humans suggest a link between insulin and cognitive performance. Do these results translate into clinical and therapeutic benefit for people with cognitive impairment? Insulin injected peripherally can readily cross the blood-brain barrier. ...

journal_title：Biochemical Society transactions

authors： Strachan MW

更新日期：2005-11-01 00:00:00

abstract：:Crystal structure data for Escherichia coli beta-ketoacyl synthase (KAS) I with C(10) and C(12) fatty acid substrates bound in conjunction with results from mutagenizing residues in the active site leads to a model for catalysis. Differences from and similarities to the other Claisen enzymes carrying out decarboxylati...

journal_title：Biochemical Society transactions

authors： von Wettstein-Knowles P,Olsen J,Arnvig Mcguire K,Larsen S

更新日期：2000-12-01 00:00:00

abstract：:Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to av...

journal_title：Biochemical Society transactions

authors： Smith LM,May RC

更新日期：2013-04-01 00:00:00

abstract：:Mitochondria are central to the health of eukaryotic cells. While commonly known for their bioenergetic role, mitochondria also function as signaling organelles that regulate cell stress responses capable of restoring homeostasis or leading the stressed cell to eventual death. Damage to the plasma membrane is a potent...

journal_title：Biochemical Society transactions

authors： Horn A,Jaiswal JK

更新日期：2020-10-30 00:00:00

abstract：:We have identified two basic residues that are important for the recognition of secretin and vasoactive intestinal peptide (VIP) by their respective receptors. These two peptides containing an Asp residue at position 3 interacted with an arginine residue in transmembrane helix 2 (TM2) of the receptor, and the lysine r...

journal_title：Biochemical Society transactions

authors： Waelbroeck M,Perret J,Vertongen P,Van Craenenbroeck M,Robberecht P

更新日期：2002-08-01 00:00:00

abstract：:Human CD4 T helper lymphocytes can be subdivided into at least three distinct functional subsets on the basis of their cytokine secretion profiles. One type of CD4+ lymphocyte, T helper 1 (Th1), produces interferon (IFN)-gamma and tumour necrosis factor beta, a second type (Th2) produces interleukin (IL)-4 and IL-5 an...

journal_title：Biochemical Society transactions

authors： Piccinni MP,Maggi E,Romagnani S

更新日期：2000-02-01 00:00:00

abstract：:There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI(3,5)P2 and PI(3,4,5)P3. Receptor activation of Class I PI3Ks stimulates the phosphorylation of PI(4,5)P2 to form PI(3,4,5)P3. PI(3,4,5)P3 is an important messenger molecule that is part...

journal_title：Biochemical Society transactions

authors： Hawkins PT,Stephens LR

更新日期：2016-02-01 00:00:00

abstract：:Besides stomata, the photosynthetic CO2 pathway also involves the transport of CO2 from the sub-stomatal air spaces inside to the carboxylation sites in the chloroplast stroma, where Rubisco is located. This pathway is far to be a simple and direct way, formed by series of consecutive barriers that the CO2 should cros...

journal_title：Biochemical Society transactions

authors： Gago J,Daloso DM,Carriquí M,Nadal M,Morales M,Araújo WL,Nunes-Nesi A,Flexas J

更新日期：2020-04-29 00:00:00

abstract：:Cyclin A must be degraded at prometaphase in order to allow mitosis progression. Nevertheless, the signals that trigger cyclin A degradation at mitosis have been largely elusive. In the present paper, we review the status of cyclin A degradation in the light of recent evidence indicating that acetylation plays a role ...

journal_title：Biochemical Society transactions

authors： Mateo F,Vidal-Laliena M,Pujol MJ,Bachs O

更新日期：2010-02-01 00:00:00

abstract：:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

journal_title：Biochemical Society transactions

authors： Deranieh RM,Greenberg ML

更新日期：2009-10-01 00:00:00

abstract：:Saccharomyces cerevisiae cells grown in glucose have larger average size than cells grown in ethanol. Besides, yeast must reach a carbon source-modulated critical cell size in order to enter S phase at Start. This control is of outmost physiological relevance, since it allows us to coordinate cell growth with cell cyc...

journal_title：Biochemical Society transactions

authors： Vanoni M,Rossi RL,Querin L,Zinzalla V,Alberghina L

更新日期：2005-02-01 00:00:00

abstract：:Anaphase B spindle elongation plays an important role in chromosome segregation. In the present paper, we discuss our model for anaphase B in Drosophila syncytial embryos, in which spindle elongation depends on an ip (interpolar) MT (microtubule) sliding filament mechanism generated by homotetrameric kinesin-5 motors ...

journal_title：Biochemical Society transactions

authors： Brust-Mascher I,Scholey JM

更新日期：2011-10-01 00:00:00

abstract：:After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of recent study results. We outline in this review how a neuroprotective candidate drug should be developed, beginning with a thorough preclinical evaluation according to the STAIR (Stroke Therapy Academic Industry Roundtab...

journal_title：Biochemical Society transactions

authors： Schäbitz WR,Fisher M

更新日期：2006-12-01 00:00:00

abstract：:Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensiv...

journal_title：Biochemical Society transactions

authors： Brandon NJ

更新日期：2007-11-01 00:00:00

abstract：:Moonlighting proteins serve one or more novel functions in addition to their canonical roles. Moonlighting functions arise when an adventitious interaction between a protein and a new partner improves fitness of the organism. Selective pressure for improvement in the new function can result in two alternative outcomes...

journal_title：Biochemical Society transactions

authors： Copley SD

更新日期：2014-12-01 00:00:00

abstract：:RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 h...

journal_title：Biochemical Society transactions

authors： Pashler AL,Towler BP,Jones CI,Newbury SF

更新日期：2016-10-15 00:00:00

abstract：:In order for cells to divide in a proficient manner, they must first double their biomass, which is considered to be the main rate-limiting phase of cell proliferation. Cell growth requires an abundance of energy and biosynthetic precursors such as lipids and amino acids. Consequently, the energy and nutrient status o...

journal_title：Biochemical Society transactions

authors： Dunlop EA,Tee AR

更新日期：2013-08-01 00:00:00

abstract：:In the intracellular microenvironment of active muscle tissue, high rates of respiration are maintained at near-limiting oxygen concentrations. The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates...

journal_title：Biochemical Society transactions

authors： Gnaiger E,Kuznetsov AV

更新日期：2002-04-01 00:00:00

abstract：:AS (alternative splicing) is a post-transcriptional process which regulates gene expression through increasing protein complexity and modulating mRNA transcript levels. Regulation of AS depends on interactions between trans-acting protein factors and cis-acting signals in the pre-mRNA (precursor mRNA) transcripts, ter...

journal_title：Biochemical Society transactions

authors： Simpson CG,Manthri S,Raczynska KD,Kalyna M,Lewandowska D,Kusenda B,Maronova M,Szweykowska-Kulinska Z,Jarmolowski A,Barta A,Brown JW

更新日期：2010-04-01 00:00:00

abstract：:It is clear that considerable conformational distortions may occur in peripheral proteins on interaction with anionic lipid bilayers. Specific lipid interactions do occur at least in the case of cytochrome c, and each perturbation and interaction may well take place before insertion into, or translocation across, a bi...

journal_title：Biochemical Society transactions

authors： Watts A

更新日期：1997-08-01 00:00:00

abstract：:There is strong evidence for an important role for increased COX (cyclo-oxygenase)-2 expression and PG (prostaglandin) E2 production in colorectal tumorigenesis. PGE(2) acts through four E-prostanoid receptors (EP1-4). COX-2 has therefore become a target for the potential chemoprevention and therapy of colorectal canc...

journal_title：Biochemical Society transactions

authors： Chell S,Patsos HA,Qualtrough D,H-Zadeh AM,Hicks DJ,Kaidi A,Witherden IR,Williams AC,Paraskeva C

更新日期：2005-08-01 00:00:00

abstract：:The fission yeast Schizosaccharomyces pombe primarily detects glucose via a cAMP-signalling pathway. Components of this pathway include the Git3 G-protein-coupled receptor and a heterotrimeric G-protein, from which the Gpa2 Galpha subunit activates adenylate cyclase (Git2/Cyr1). Three additional proteins, Git1, Git7 a...

journal_title：Biochemical Society transactions

authors： Hoffman CS

更新日期：2005-02-01 00:00:00

abstract：:The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in epigenetic gene silencing. Variations in the SMCHD1 gene are associated with two debilitating human disorders, facioscapulohumeral muscular dystrophy (FSHD) and Bosma arhinia microphthalmia s...

journal_title：Biochemical Society transactions

authors： Gurzau AD,Blewitt ME,Czabotar PE,Murphy JM,Birkinshaw RW

更新日期：2020-08-28 00:00:00

abstract：:Studies on those enzymes and electron-transfer proteins involved in the catabolism of 'C1' substrates in methylotrophic bacteria have provided a wealth of information concerning the transfer of electrons and hydrogen by quantum tunnelling mechanisms. With regard to H-transfer, studies with MADH have provided the first...

journal_title：Biochemical Society transactions

authors： Scrutton NS

更新日期：1999-12-01 00:00:00

abstract：:ATP-binding cassette (ABC) transporters play crucial roles in cellular processes, such as nutrient uptake, drug resistance, cell-volume regulation and others. Despite their importance, all proposed molecular models for transport are based on indirect evidence, i.e. functional interpretation of static crystal structure...

journal_title：Biochemical Society transactions

authors： Husada F,Gouridis G,Vietrov R,Schuurman-Wolters GK,Ploetz E,de Boer M,Poolman B,Cordes T

更新日期：2015-10-01 00:00:00

abstract：:Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of ...

journal_title：Biochemical Society transactions

authors： Heikel G,Choudhury NR,Michlewski G

更新日期：2016-08-15 00:00:00

abstract：:Human heparan sulphate N-deacetylase/N-sulphotransferase 1 sulphates the NH(3) (+) group of the glucosamine moiety of the heparan chain in heparan sulphate/heparin biosynthesis. An open cleft that runs perpendicular to the sulphate donor 3'-phosphoadenosine 5'-phosphosulphate may constitute the acceptor substrate-bind...

journal_title：Biochemical Society transactions

authors： Kakuta Y,Li L,Pedersen LC,Pedersen LG,Negishi M

更新日期：2003-04-01 00:00:00

abstract：:Dissimilatory metal-reducing bacteria are able to conduct electrons from their cytoplasmic membrane across the periplasm and the outer membrane to redox proteins located on the surface of their cells. The Mtr respiratory pathway in Shewanella is the best-understood metal-reducing pathway to date. The core components o...

journal_title：Biochemical Society transactions

authors： Gralnick JA

更新日期：2012-12-01 00:00:00

abstract：:Large dense-core vesicles (LDCVs) were labelled in cultured bovine adrenal chromaffin cells expressing fluorescent chimaeric 'cargo' proteins that were targeted to these secretory vesicles. When the cells were stimulated with nicotine 48 h after transduction, the fractional loss of fluorescent LDCVs was much greater t...

journal_title：Biochemical Society transactions

authors： Wiegand UK,Duncan RR,Greaves J,Chow RH,Shipston MJ,Apps DK

更新日期：2003-08-01 00:00:00