Takeover of host ribosomes by divergent IRES elements.

Abstract:

:The ribosome is the macromolecular machinery in the host cell for which all viruses have to compete. Early in infection, the viral mRNAs have to compete with the host for both the ribosomes and for the limited pool of eukaryotic initiation factors that are needed to facilitate the recruitment of ribosomes to both viral and cellular mRNAs. To circumvent this competition, certain viruses have evolved to recruit ribosomes to IRESs (internal ribosome entry sites), highly specialized RNA elements that are located at the 5'-end of the viral genomes. Here, we discuss how divergent IRES elements can recruit ribosomes and start protein synthesis with only a minimal set of eukaryotic translation initiation factors, and how this mode of translation initiation aids viral gene amplification during early onset of innate immune responses.

journal_name

Biochem Soc Trans

authors

Sarnow P,Cevallos RC,Jan E

doi

10.1042/BST20051479

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1479-82

issue

Pt 6

eissn

0300-5127

issn

1470-8752

pii

BST20051479

journal_volume

33

pub_type

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