Abstract:
:The 'fusion peptides' of a group of enveloped viruses that includes influenza, paramyxo-, retro-and filo-viruses are N-terminal regions of their membrane fusion proteins generated by cleavage of non-functional precursors. For the influenza membrane fusion protein, haemagglutinin (HA), the three-dimensional structures of precursor HA, cleaved HA and fusion-activated HA show that the fusion peptides are located in different positions in all three forms and adopt different structures. Analyses of mutant HAs with changes in fusion peptide sequence indicate the importance of specific residues for membrane-fusion activity and suggest a structure for the fusion peptide in a fusion-active molecule.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Skehel JJ,Cross K,Steinhauer D,Wiley DCdoi
10.1042/bst0290623keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
623-6issue
Pt 4eissn
0300-5127issn
1470-8752journal_volume
29pub_type
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