Abstract:
:PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local conformational changes. Here, we summarize some new insights gathered from recent studies on the commonly occurring single-domain PilZ proteins, YcgR-like proteins and PilZ domain-containing cellulose synthases. The studies collectively illuminate how PilZ domains function as cis- or trans-regulatory domains that enable c-di-GMP to control the activity of its cellular targets. Overall, the review highlights the diverse protein structure, biological function and regulatory mechanism of PilZ domain-containing proteins, as well as the challenge of deciphering the function and mechanism of orphan PilZ proteins.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Cheang QW,Xin L,Chea RYF,Liang ZXdoi
10.1042/BST20180543subject
Has Abstractpub_date
2019-02-28 00:00:00pages
381-388issue
1eissn
0300-5127issn
1470-8752pii
BST20180543journal_volume
47pub_type
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