Abstract:
:The Ca2+-mobilizing second messenger, NAADP (nicotinic acid adenine dinucleotide phosphate), has been with us for nearly 20 years and yet we still cannot fully agree on the identity of its target Ca2+-release channel. In spite of some recent robust challenges to the idea that two-pore channels (TPCs) represent the elusive "NAADP receptor", evidence continues to accumulate that TPCs are important for NAADP-mediated responses. This article will briefly outline the background and review more recent work pertaining to the TPC story.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Morgan AJ,Davis LC,Ruas M,Galione Adoi
10.1042/BST20140300subject
Has Abstractpub_date
2015-06-01 00:00:00pages
384-9issue
3eissn
0300-5127issn
1470-8752pii
BST20140300journal_volume
43pub_type
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