Abstract:
:Along with the development of several large-scale methods such as mass spectrometry or micro arrays, genome wide models became not only a possibility but an obvious tool for theoretical biologists to integrate and analyse complex biological data. Nevertheless, incorporating the dynamics of photosynthesis remains one of the major challenges while reconstructing metabolic networks of plants and other photosynthetic organisms. In this review, we aim to provide arguments that small-scale models are still a suitable choice when it comes to discovering organisational principles governing the design of biological systems. We give a brief overview of recent modelling efforts in understanding the interplay between rapid, photoprotective mechanisms and the redox balance within the thylakoid membrane, discussing the applicability of a reductionist approach in modelling self-regulation in plants and outline possible directions for further research.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Matuszyńska A,Ebenhöh Odoi
10.1042/BST20150136subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1133-9issue
6eissn
0300-5127issn
1470-8752pii
BST20150136journal_volume
43pub_type
杂志文章,评审abstract::XRCC4 (X-ray cross-complementation group 4) and XLF (XRCC4-like factor) are two essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that repairs DNA DSBs (double-strand breaks). The individual crystal structures show that the dimeric proteins are homologues with protomers containing h...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0391387
更新日期:2011-10-01 00:00:00
abstract::Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular c...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20140205
更新日期:2014-12-01 00:00:00
abstract::Enzymes of the 1-deoxy-D-xylulose 5-phosphate/2-C-methylerythritol 4-phosphate (DOXP/MEP) pathway are targets for new herbicides and antibacterial drugs. Until now, no inhibitors for the DOXP synthase have been known of. We show that one of the breakdown products of the herbicide clomazone affects the DOXP synthase. O...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20150079
更新日期:2015-10-01 00:00:00
abstract::In the present article, I discuss recent developments in the naming of the TOR (target of rapamycin) protein. In particular, I address the issue of mammalian target of rapamycin (mTOR) versus the newer mechanistic target of rapamycin (MTOR). mTOR is the name given by the TOR community almost two decades ago and widely...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20130092
更新日期:2013-08-01 00:00:00
abstract::The human RAD30B gene has recently been shown to encode a novel DNA polymerase, DNA polymerase iota (poliota). The role of poliota within the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterization in vitro. The aim of this short review is, therefore, to summar...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/0300-5127:0290183
更新日期:2001-05-01 00:00:00
abstract::Sugars that are readily respired by plant cells inhibit greening when dO2 and mu are relatively high. As sugar concentration in the batch culture medium is depleted and mu declines, greening is permitted. The mechanism of this effect has not been satisfactorily explained. ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0080475
更新日期:1980-08-01 00:00:00
abstract::In cruciferous plants, the primary pre-rRNA cleavage site (P site) is immediately downstream of four similar, highly conserved sequences (A(1), A(2), A(3) and B) located within the 5'-ETS (5'-external transcribed spacer). In the present study, we describe the characterization of a plant NF D (nuclear factor D) that bi...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0320578
更新日期:2004-08-01 00:00:00
abstract::It is generally taken as an established fact that mitochondrial respiration is associated with the generation of small amounts of ROS (reactive oxygen species). There are many arguments supporting this side activity. A major argument is the particular physico-chemical configuration of dioxygen, which prevents the tran...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0311308
更新日期:2003-12-01 00:00:00
abstract::Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokine...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20190109
更新日期:2020-06-30 00:00:00
abstract::The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated protein...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20140270
更新日期:2015-04-01 00:00:00
abstract::The human prostate expresses very high concentrations of annexins 1, 4, and 5 and secretes high concentrations of annexins 1 and 5. Although the biological roles of these proteins in prostate secretions are not known, these studies emphasize the need to consider extracellular sites for physiological functions of annex...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0181104
更新日期:1990-12-01 00:00:00
abstract::GRIF-1 [GABA(A) (gamma-aminobutyric acid(A)) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail the molecular interaction between GRIF-1 a...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0340048
更新日期:2006-02-01 00:00:00
abstract::The glutamate/aspartate transporter GLAST-1 is expressed in bone in vivo and also exists as a splice variant (GLAST-1a) in which exon 3 is excluded. Since GLAST-1 expression is regulated in bone in response to osteogenic mechanical stimuli in vivo and binding of glutamate to receptors on osteoblasts increases osteobla...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/bst0300890
更新日期:2002-11-01 00:00:00
abstract::Numerous RNA molecules with new catalytic properties have been isolated from synthetic combinatorial libraries. A broad range of chemical reactions is catalysed, and nucleic acids can accelerate bond formation between small organic substrates. This review focuses on carbon-carbon bond formation accelerated by in vitro...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0301137
更新日期:2002-11-01 00:00:00
abstract::It is clear that considerable conformational distortions may occur in peripheral proteins on interaction with anionic lipid bilayers. Specific lipid interactions do occur at least in the case of cytochrome c, and each perturbation and interaction may well take place before insertion into, or translocation across, a bi...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0251119
更新日期:1997-08-01 00:00:00
abstract::PTEN (phosphatase and tensin homologue deleted on chromosome 10) is an important tumour-suppressor gene that encodes a 3-phosphatase. The major substrate of PTEN is PIP(3) (phosphatidylinositol 3,4,5-trisphosphate) generated by the action of PI3Ks (phosphoinositide 3-kinases). Hereditary mutation of PTEN causes tumour...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0350172
更新日期:2007-04-01 00:00:00
abstract::CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins or ONs (oligonucleotides). CPPs and their conjugates were initially thought to translocate through the cell membrane by a non-endocytotic mechanism which has recently been re-evaluated. Basic-a...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0350053
更新日期:2007-02-01 00:00:00
abstract::The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu(2+) ions, as well as novel N(1)- and N(12)-Ac-SpmTriens and bis-Et-SpmTrien (N(1),N(12)-diethyl-1,12-diamino-3,6,9-triazadodecane) are describe...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0350369
更新日期:2007-04-01 00:00:00
abstract::Human adipose tissue has an important protein secretory function. Cytokines, hormones, prohormones and enzymes are secreted from fat cells and act in an endocrine or paracrine fashion. The production of several of these proteins is affected by obesity; normally there is an increase in the obese state. Protein producti...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0290072
更新日期:2001-05-01 00:00:00
abstract::Photosynthesis is fundamental to biomass production, but is a dynamic process sensitive to environmental constraints. In recent years, approaches to increase biomass and grain yield by altering photosynthetically related processes in the plant have received considerable attention. However, improving biomass yield requ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20170296
更新日期:2018-04-17 00:00:00
abstract::NRs (nuclear receptors) regulate the expression of specific gene networks in target cells by recruiting cofactor complexes involved in chromatin remodelling and in the assembly of transcription complexes. The importance of activating gene expression, in metabolic tissues, is well established, but the contribution of t...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0341103
更新日期:2006-12-01 00:00:00
abstract::Dissimilatory metal-reducing bacteria are able to conduct electrons from their cytoplasmic membrane across the periplasm and the outer membrane to redox proteins located on the surface of their cells. The Mtr respiratory pathway in Shewanella is the best-understood metal-reducing pathway to date. The core components o...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20120129
更新日期:2012-12-01 00:00:00
abstract::SOEs (sulfite-oxidizing enzymes) are physiologically vital and occur in all forms of life. During the catalytic cycle, the five-co-ordinate square pyramidal oxo-molybdenum active site passes through the Mo(V) state, and intimate details of the structure can be obtained from variable frequency pulsed EPR spectroscopy t...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0361129
更新日期:2008-12-01 00:00:00
abstract::Bloom's syndrome (BS) is a rare autosomal recessive disorder characterized by genomic instability and cancer predisposition. The underlying genetic defect is mutation of the BLM gene, producing deficiency in the RecQ helicase BLM (Bloom's syndrome protein). The present article begins by introducing BLM and its binding...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0370553
更新日期:2009-06-01 00:00:00
abstract::Brain development is a tightly controlled process that depends upon differentiation and function of neurons to allow for the formation of functional neural networks. Mutation of genes encoding structural proteins is well recognized as causal for neurodevelopmental disorders (NDDs). Recent studies have shown that aberr...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20150168
更新日期:2015-12-01 00:00:00
abstract::Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse grou...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20120266
更新日期:2013-02-01 00:00:00
abstract::Recent progress in understanding the plant NE (nuclear envelope) has resulted from significant advances in identifying and characterizing the protein constituents of the membranes and nuclear pores. Here, we review recent findings on the membrane integral and membrane-associated proteins of the key domains of the NE, ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0380307
更新日期:2010-02-01 00:00:00
abstract::Invertebrates use a wide range of peptides as transmitters and hormones to regulate complex behaviour, physiology and development. These animals, especially those that are amenable to genetic study and are the subject of genome-sequencing projects, provide powerful model systems for understanding the functions of pept...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a par...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0330423
更新日期:2005-04-01 00:00:00