Abstract:
:The lack or excess of the protein tau can be deleterious for neurons. The absence of tau can result in retarded neurogenesis and neuronal differentiation, although adult mice deficient in tau are viable, probably because of the compensation of the loss of tau by other MAPs (microtubule-associated proteins). On the contrary, the overexpression of tau can be toxic for the cell. One way to reduce intracellular tau levels can be achieved by its secretion through microvesicles to the extracellular space. Furthermore, tau can be found in the extracellular space because of the neuronal cell death occurring in neurodegenerative disorders such as Alzheimer's disease. The presence of toxic extracellular tau could be the mechanism for the spreading of tau pathology in these neurodegenerative disorders.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Avila J,de Barreda EG,Fuster-Matanzo A,Simón D,Llorens-Martín M,Engel T,Lucas JJ,Díaz-Hernández M,Hernández Fdoi
10.1042/BST20120006subject
Has Abstractpub_date
2012-08-01 00:00:00pages
653-5issue
4eissn
0300-5127issn
1470-8752pii
BST20120006journal_volume
40pub_type
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