Abstract:
:There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers are present, but in the absence of mature amyloid fibrils. The generation of ROS during early-stage protein aggregation may be a common, fundamental molecular mechanism underlying the pathogenesis of oxidative damage, neurodegeneration and cell death in several different neurodegenerative diseases. Drugs that specifically target this process could be useful in the future therapy of these diseases.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Tabner BJ,El-Agnaf OM,German MJ,Fullwood NJ,Allsop Ddoi
10.1042/BST20051082keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1082-6issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST20051082journal_volume
33pub_type
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