Abstract：
:For a disease such as cancer, where a number of alterations to normal cell function accumulate over time, there are several opportunities to inhibit, slow down or even reverse the process. Many of the changes which drive the disease process occur in cell-signalling pathways that regulate proliferation and apoptosis. As our knowledge of these complicated signalling networks improves, it is becoming clear that many molecules, both drugs and naturally occurring dietary constituents, can interact beneficially with deregulated pathways. Aspirin and other non-steroidal anti-inflammatory drugs, as well as natural compounds present in plants such as green vegetables and tea, can modulate signalling by affecting kinase activity and therefore phosphorylation of key molecules. Examples of pathways which can be modulated by these agents include activation of the transcription factor nuclear factor kappaB by tumour promoters or cytokines, signalling by growth factors through the growth-factor receptor/extracellular-regulated protein kinase pathways and by a number of other molecules through the stress-activated c-Jun N-terminal kinase and p38 pathways. These mitogen-activated protein kinase pathways regulate a number of transcription factors including c-Fos and c-Jun. Evidence exists, at least from in vitro experiments, that by targeting such pathways, certain dietary compounds may be able to restore abnormal rates of apoptosis and proliferation to more normal levels.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Manson MM,Holloway KA,Howells LM,Hudson EA,Plummer SM,Squires MS,Prigent SAdoi
10.1042/bst0280007keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
7-12issue
2eissn
0300-5127issn
1470-8752journal_volume
28pub_type
杂志文章,评审abstract：:PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP produc...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20150002
更新日期：2015-04-01 00:00:00
abstract：:Complex brains have developed specialized mechanisms for the grouping of principal cells into temporal coalitions of local or distant networks: the inhibitory interneuron 'clocking' networks. They consist of GABAergic (where GABA is gamma-aminobutyric acid) interneurons of a rich diversity. In cortical circuits, these...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0371328
更新日期：2009-12-01 00:00:00
abstract：:An extraordinary array of P450 (cytochrome P450) enzymes are encoded on the genome of the human pathogen Mycobacterium tuberculosis (Mtb) and in related mycobacteria and actinobacteria. These include the first characterized sterol 14alpha-demethylase P450 (CYP51), a known target for azole and triazole drugs in yeasts ...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0341178
更新日期：2006-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0301050
更新日期：2002-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0351485
更新日期：2007-12-01 00:00:00
abstract：:MAPK (mitogen-activated protein kinase) signalling pathways contribute to the regulation of diverse responses, including normal and pathological aspects of cell growth, division, differentiation and death. Their ubiquity and versatility raise the issue of how they achieve specific coupling of signal with cellular resp...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0340837
更新日期：2006-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0391327
更新日期：2011-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/bst0320283
更新日期：2004-04-01 00:00:00
abstract：:Degradation of cytoplasmic mRNAs is an important aspect of the regulation of gene function in eukaryotes. Much of what is currently known about the underlying pathways of mRNA decay is derived from studies of the budding yeast Saccharomyces cerevisiae, in which mRNA turnover is initiated by deadenylation, followed eit...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0381150
更新日期：2010-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0240594
更新日期：1996-05-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20051154
更新日期：2005-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0371423
更新日期：2009-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0160661
更新日期：1988-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0381474
更新日期：2010-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20150019
更新日期：2015-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20190511
更新日期：2020-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0350749
更新日期：2007-08-01 00:00:00
abstract：:PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within surviving neurons. Although heritability st...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0330586
更新日期：2005-08-01 00:00:00
abstract：:Findings from gene expression profiling studies are leading to new diagnostic and therapeutic strategies that can be applied in medical practice, especially in the field of oncology. Promising results of gene expression profiling of the peripheral blood in patients with ischaemic stroke have been obtained in recent pi...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0341313
更新日期：2006-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20180469
更新日期：2018-12-17 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/
更新日期：2002-04-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20140205
更新日期：2014-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20140019
更新日期：2014-04-01 00:00:00
abstract：:The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby pr...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0340711
更新日期：2006-11-01 00:00:00
abstract：:Loss of barrier function in the vasculature promotes inflammatory signalling which in turn contributes to the progression of cardiovascular disease. cAMP can protect against endothelial dysfunction through the effectors PKA (protein kinase A) and Epac (exchange protein directly activated by cAMP). The present review o...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20130271
更新日期：2014-04-01 00:00:00
abstract：:Formin family proteins (formins) represent an evolutionary conserved protein family encoded in the genome of a wide range of eukaryotes. Formins are hallmarked by a formin homology 1 (FH1) domain juxtaposed to an FH2 domain whereby they control actin and microtubule dynamics. Not surprisingly, formins are best known a...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20160187
更新日期：2016-12-15 00:00:00
abstract：:Seeds of rape (Brassica napus L.) were germinated at various NaCl concentrations up to 200 mM. Germinating levels, seedling growth, triacylglycerol mobilization and lipase activity were investigated. High salt concentrations resulted in retardation of seed germination. Seedling growth as measured by radicle length was...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:RDCs (residual dipolar couplings) in NMR spectroscopy provide information about protein dynamics complementary to NMR relaxation methods, especially in the previously inaccessible time window between the protein correlation time tau(c) and 50 micros. For ubiquitin, new modes of motion of the protein backbone could be ...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0361433
更新日期：2008-12-01 00:00:00
abstract：:Native disulphide bonds are essential for the structure and function of many membrane and secretory proteins. Disulphide bonds are formed, reduced and isomerized in the endoplasmic reticulum of mammalian cells by a family of oxidoreductases, which includes protein disulphide isomerase (PDI), ERp57, ERp72, P5 and PDIR....
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0320655
更新日期：2004-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20120073
更新日期：2012-06-01 00:00:00
