Abstract：
:Horses and other equids are unusual in producing protein-rich sweat for thermoregulation, a major component of which is latherin, a highly surface-active, non-glycosylated protein that is a member of the PLUNC (palate, lung and nasal epithelium clone) family. Latherin produces a significant reduction in water surface tension at low concentrations (≤1 mg/ml), and probably acts as a wetting agent to facilitate evaporative cooling through a thick, waterproofed pelt. Latherin binds temporarily to hydrophobic surfaces, and so may also have a disruptive effect on microbial biofilms. It may consequently have a dual role in horse sweat in both evaporative cooling and controlling microbial growth in the pelt that would otherwise be resourced by nutrients in sweat. Latherin is also present at high levels in horse saliva, where its role could be to improve mastication of the fibrous diet of equids, and also to reduce microbial adherence to teeth and oral surfaces. Neutron reflection experiments indicate that latherin adsorbs to the air/water interface, and that the protein undergoes significant conformational change and/or partial unfolding during incorporation into the interfacial layer.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Kennedy MWdoi
10.1042/BST0391017subject
Has Abstractpub_date
2011-08-01 00:00:00pages
1017-22issue
4eissn
0300-5127issn
1470-8752pii
BST0391017journal_volume
39pub_type
杂志文章abstract：:Synthetic gene circuits allow us to govern cell behavior in a programmable manner, which is central to almost any application aiming to harness engineered living cells for user-defined tasks. Transcription factors (TFs) constitute the 'classic' tool for synthetic circuit construction but some of their inherent constra...
journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20200020
更新日期：2020-10-30 00:00:00
abstract：:In plant and metazoan, Polycomb Group (PcG) proteins play key roles in regulating developmental processes by repression of gene expression. PcG proteins function as multi-protein complexes; among them the best characterized ones are Polycomb Repressive Complex 1 (PRC1) and PRC2. PRC2 catalyzes histone H3 lysine 27 tri...
journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0370762
更新日期：2009-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20170404
更新日期：2018-08-20 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20060017
更新日期：2006-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2007-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0290072
更新日期：2001-05-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0391327
更新日期：2011-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0380613
更新日期：2010-04-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0350421
更新日期：2007-04-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/bst0211124
更新日期：1993-11-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20150019
更新日期：2015-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0361066
更新日期：2008-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0380747
更新日期：2010-06-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20120006
更新日期：2012-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST20140036
更新日期：2014-04-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/bst0280063
更新日期：2000-02-01 00:00:00
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journal_title：Biochemical Society transactions
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2019-02-28 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
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更新日期：2017-04-15 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/bst0280109
更新日期：2000-02-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0351529
更新日期：2007-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
doi：10.1042/BST0341103
更新日期：2006-12-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章
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更新日期：2005-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST20130024
更新日期：2013-10-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0381150
更新日期：2010-08-01 00:00:00
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journal_title：Biochemical Society transactions
pub_type： 杂志文章,评审
doi：10.1042/BST0380395
更新日期：2010-04-01 00:00:00
