Abstract:
:The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Barwell J,Wheatley M,Conner AC,Taddese B,Vohra S,Reynolds CA,Poyner DRdoi
10.1042/BST20120251subject
Has Abstractpub_date
2013-02-01 00:00:00pages
180-4issue
1eissn
0300-5127issn
1470-8752pii
BST20120251journal_volume
41pub_type
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