Abstract:
:Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly based on repeat unit length, with subclasses representing specific folds. Sequence-based classifications, such as Pfam, provide an alternative classification based on evolutionarily conserved repeat families. Here, we discuss a detailed comparison between the structural classes in RepeatsDB and the corresponding Pfam repeat families and clans. Most instances are found to map one-to-one between structure and sequence. Some notable exceptions such as leucine-rich repeats (LRRs) and α-solenoids are discussed.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Paladin L,Tosatto SCdoi
10.1042/BST20150079subject
Has Abstractpub_date
2015-10-01 00:00:00pages
832-7issue
5eissn
0300-5127issn
1470-8752pii
BST20150079journal_volume
43pub_type
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