Comparison of protein repeat classifications based on structure and sequence families.

Abstract:

:Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly based on repeat unit length, with subclasses representing specific folds. Sequence-based classifications, such as Pfam, provide an alternative classification based on evolutionarily conserved repeat families. Here, we discuss a detailed comparison between the structural classes in RepeatsDB and the corresponding Pfam repeat families and clans. Most instances are found to map one-to-one between structure and sequence. Some notable exceptions such as leucine-rich repeats (LRRs) and α-solenoids are discussed.

journal_name

Biochem Soc Trans

authors

Paladin L,Tosatto SC

doi

10.1042/BST20150079

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

832-7

issue

5

eissn

0300-5127

issn

1470-8752

pii

BST20150079

journal_volume

43

pub_type

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