Regulation of the pyruvate dehydrogenase complex.

Abstract:

:The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. The former regulatory mechanism involving multiple phosphorylation sites and tissue-specific distribution of the dedicated kinases and phosphatases is not only dependent on the interactions among the catalytic and regulatory components of the complex but also sensitive to the intramitochondrial redox state and metabolite levels as indicators of the energy status. Furthermore, differential transcriptional controls of the regulatory components of PDC further add to the complexity needed for long-term tuning of PDC activity for the maintenance of glucose homoeostasis during normal and disease states.

journal_name

Biochem Soc Trans

authors

Patel MS,Korotchkina LG

doi

10.1042/BST20060217

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

217-22

issue

Pt 2

eissn

0300-5127

issn

1470-8752

pii

BST20060217

journal_volume

34

pub_type

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