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Multiple processing of procathepsin L to cathepsin L in vivo.

Abstract：

:Three amino-terminal-specific peptidic antibodies against cathepsin L were generated. These antibodies recognize in vitro processing products of procathepsin L in time-course-dependent fashion. Immunoblot analyses with these antibodies followed by immunoprecipitation with anti-cathepsin L antibody showed that the amino terminal amino acid sequences of intracellular cathepsin L are heterogeneous: the single chain form of cathepsin L starts with either EPLML, LKIPK or IPKSV, and the heavy chain of the two chain form with IPKSV. Percoll density gradient and fluorescence immunohistochemistry suggested that these three species of cathepsin L localize in the lysosomes where procathepsin L processing occurs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishidoh K,Saido TC,Kawashima S,Hirose M,Watanabe S,Sato N,Kominami E

doi

10.1006/bbrc.1998.9613

subject

Has Abstract

pub_date

1998-11-09 00:00:00

pages

202-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)99613-9

journal_volume

252

pub_type

杂志文章

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