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Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment.

Abstract：

:AIDS patients (2 groups) had a blood deficiency (p less than 0.001) of coenzyme Q10 vs. 2 control groups. AIDS patients had a greater deficiency (p less than 0.01) than ARC patients. ARC patients had a deficiency (p less than 0.05) vs. control. HIV-infected patients had a deficiency (p less than 0.05) vs. control. The deficiency of CoQ10 increased with the increased severity of the disease, i.e., from HIV positive (no symptoms) to ARC (constitutional symptoms, no opportunistic infection or tumor) to AIDS (HIV infection, opportunistic infection and/or tumor). This deficiency, a decade of data on CoQ10 on the immune system, on IgG levels, on hematological activity constituted the rationale for treatment with CoQ10 of 7 patients with AIDS or ARC. One was lost to follow-up; one expired after stopping CoQ10; 5 survived, were symptomatically improved with no opportunistic infection after 4-7 months. In spite of poor compliance of 5/7 patients, the treatment was very encouraging and at times even striking.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Folkers K,Langsjoen P,Nara Y,Muratsu K,Komorowski J,Richardson PC,Smith TH

doi

10.1016/s0006-291x(88)81179-3

subject

Has Abstract

pub_date

1988-06-16 00:00:00

pages

888-96

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81179-3

journal_volume

153

pub_type

杂志文章

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