abstract：:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The ...

journal_title：Biochemical and biophysical research communications

authors： Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

更新日期：2021-02-05 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A), a type of metalloproteinase in the insulin-like growth factor (IGF) system, has been implicated in atherosclerosis progression, but its function and mechanism in atherosclerosis is not fully understood. The study was performed to further explore the effects of PAPP-A on ...

journal_title：Biochemical and biophysical research communications

authors： Wang G,Liu X,Li X,Zhao Y

更新日期：2021-01-25 00:00:00

abstract：:Dental fluorosis is characterized by hypomineralization of tooth enamel caused by ingestion of excessive fluoride during enamel formation. Excess fluoride could have effects on the ERK signaling, which is essential for the ameloblasts differentiation and tooth development. MAP kinase phosphatase-1 (MKP-1) plays a crit...

journal_title：Biochemical and biophysical research communications

authors： Zhao L,Su J,Liu S,Li Y,Xi T,Ruan J,Liang KX,Huang R

更新日期：2021-01-22 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a major challenge in clinical practice due to its aggressiveness and lack of targeted treatment. Cancer stem-like traits contribute to tumorigenesis and immune privilege of TNBC. However, the relationship of stemness and immunosurveillance remains unclear. Here, we demonstrate t...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Gao L,Qi M,Su P,Xiong X,Zhao J,Hu J,Han B

更新日期：2021-01-22 00:00:00

abstract：:Inflammatory bowel disease (IBD) comprises two major subtypes, ulcerative colitis (UC) and Crohn's disease, which are multifactorial diseases that may develop due to genetic susceptibility, dysbiosis, or environmental factors. Environmental triggers of IBD include food-borne factors, and a previous nationwide survey i...

journal_title：Biochemical and biophysical research communications

authors： Tsuchiya M,Ito G,Hama M,Nagata S,Kawamoto A,Suzuki K,Shimizu H,Anzai S,Takahashi J,Kuno R,Takeoka S,Hiraguri Y,Sugihara HY,Mizutani T,Yui S,Oshima S,Tsuchiya K,Watanabe M,Okamoto R

更新日期：2021-01-20 00:00:00

abstract：:Tuberous sclerosis complex 2 (TSC2) is a tumor-suppressor protein that is partially regulated by insulin, energy, oxygen, and growth factors. Mutations in the TSC2 gene and loss of TSC2 promote cell growth by the mammalian target of rapamycin complex 1 (mTORC1) activation. Furthermore, S-adenosylmethionine (SAM) senso...

journal_title：Biochemical and biophysical research communications

authors： Gen S,Matsumoto Y,Suzuki T,Inoue J,Yamamoto Y

更新日期：2021-01-19 00:00:00

abstract：:Loss of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) expression closely associates with increased aggressive behaviors of oral carcinoma cells. It emphasizes that a mechanism to suppress the expression is an important subject for understanding carcinoma progression pathway. However, nothi...

journal_title：Biochemical and biophysical research communications

authors： Nozawa T,Mihara-Tomiyama N,Chiba T,Imai K

更新日期：2021-01-19 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cancer cells are usually insensitive to TRAIL so reducing this drug resistance may improve the treatment of gastric cancer. In thi...

journal_title：Biochemical and biophysical research communications

authors： Li H,Lv J,Guo J,Wang S,Liu S,Ma Y,Liang Z,Wang Y,Qi W,Qiu W

更新日期：2021-01-18 00:00:00

abstract：:Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating e...

journal_title：Biochemical and biophysical research communications

authors： Lee SW,Moon SW,Park JS,Suh HR,Han HC

更新日期：2021-01-16 00:00:00

abstract：BACKGROUND:Chronic hypoxia plays an important role in the initiation and progression of chronic renal disease. The pathogenic role of chronic hypoxia in tubulointerstitial injury has been investigated widely, but little is known about acute hypoxia implications in glomerular damage. In this study, we investigated the e...

journal_title：Biochemical and biophysical research communications

authors： Hu G,He Y,Li Y,Hu X,Liu S,Liao C,Zhang R,Zhou X,Sun H

更新日期：2021-01-12 00:00:00

abstract：:Nitrogen heterocycle small molecules display various pharmaceutically important bioactivities and have great potential in drug development and application. Microbes are an important source for discovering nitrogen heterocycle natural products, and the elucidation of their biosynthetic pathways in microbes facilitates ...

journal_title：Biochemical and biophysical research communications

authors： Chai S,Cao M,Feng Z

更新日期：2021-01-11 00:00:00

abstract：:Down syndrome (DS, Trisomy 21) is the most common genetic cause of delayed fetal brain development and postnatal intellectual disability. Although delayed fetal brain development might be involved in intellectual disability, no evidence of an association between these abnormal phenotypes has been shown. To identify mo...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Ishihara K,Kawashita E,Sago H,Yamakawa K,Mizutani KI,Akiba S

更新日期：2021-01-08 00:00:00

abstract：:Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increa...

journal_title：Biochemical and biophysical research communications

authors： Hu D,Li D,Shigeta M,Ochi Y,Okauchi T,Neyama H,Kabayama S,Watanabe Y,Cui Y

更新日期：2021-01-08 00:00:00

abstract：:The tumor suppressor p53 is involved in cadmium (Cd)-induced apoptosis and autophagy. However, the regulatory mechanisms of p53 in Cd-induced kidney injury are not well established. Here, we report the role of autophagy in Cd-induced p53 induction in human proximal tubular cells (HK-2). HK-2 cells treated with Cd indu...

journal_title：Biochemical and biophysical research communications

authors： Lee HY,Oh SH

更新日期：2021-01-01 00:00:00

abstract：:Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in cancer therapy. Howev...

journal_title：Biochemical and biophysical research communications

authors： Heim C,Maiwald S,Steinebach C,Collins MK,Strope J,Chau CH,Figg WD,Gütschow M,Hartmann MD

更新日期：2021-01-01 00:00:00

abstract：:Vaccination evoking immunity in susceptible individuals has become the most effective solution to combat infectious diseases. The surface antigen of hepatitis B virus (HBsAg) is a mandatory vaccine for children in China. Herein, we designed an antimicrobial protein consisting of an antimicrobial peptide Thanatin at th...

journal_title：Biochemical and biophysical research communications

authors： Fan X,Xu W,Gao W,Xiao H,Wu G

更新日期：2021-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine associated with inflammation, immune responses, and autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, and psoriasis. In the present study, we performed in vitro selection, systematic evolution of ligands by exponential enric...

journal_title：Biochemical and biophysical research communications

authors： Tsukamoto K,Ando T,Fuji D,Yokoyama T,Takamori Y,Horiuchi D,Iwamoto R,Yamamoto M,Kawakami T

更新日期：2021-01-01 00:00:00

abstract：:Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baica...

journal_title：Biochemical and biophysical research communications

authors： Xiao T,Cui Y,Ji H,Yan L,Pei D,Qu S

更新日期：2021-01-01 00:00:00

abstract：:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore...

journal_title：Biochemical and biophysical research communications

authors： Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

更新日期：2021-01-01 00:00:00

abstract：:Cigarette smoke is a major cause of chronic obstructive pulmonary disease (COPD). Circular RNAs (circRNAs) are involved in regulating various biological processes. This study aimed to explore the role and molecular basis of hsa_circ_0006872 in cigarette smoke extract (CSE)-induced cell injury. HPMECs and BEAS-2B cells...

journal_title：Biochemical and biophysical research communications

authors： Xue M,Peng N,Zhu X,Zhang H

更新日期：2021-01-01 00:00:00

abstract：:Although major depressive disorder (MDD) has caused severe mental harm to overwhelming amounts of patients, the pathogenesis of MDD remains to be studied. Due to the in-depth discussion of the mechanism of new antidepressants like ketamine, the habenula (Hb) was reported to be significant in the onset of MDD and the a...

journal_title：Biochemical and biophysical research communications

authors： Tian Y,Wu Z,Wang Y,Chen C,He Y,Lan T,Li Y,Bai M,Yu H,Chen X,Chen Z,Cheng K,Xie P

更新日期：2021-01-01 00:00:00

abstract：:PLRG1 is a evolutionarily conserved protein in spliceosome and plays an important role in maintaining the integral part of the splicoeosme and its proper splicing. Here we solved the high resolution crystal structure of the WD40 domain of human PLRG1 by crystallography and compared our crystal structure with the cryo-...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Li Y,Dai H,Xu C

更新日期：2021-01-01 00:00:00

abstract：:In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in the brain reward system. Using a conditional place preference test, the rewarding effect was clearly evoked by scratching under both acute and chronic itch stimuli. The induc...

journal_title：Biochemical and biophysical research communications

authors： Setsu T,Hamada Y,Oikawa D,Mori T,Ishiuji Y,Sato D,Narita M,Miyazaki S,Furuta E,Suda Y,Sakai H,Ochiya T,Tezuka H,Iseki M,Inada E,Yamanaka A,Kuzumaki N,Narita M

更新日期：2021-01-01 00:00:00

abstract：:Aldosterone is synthesized in the adrenal by the aldosterone synthase CYP11B2. Although the control of CYP11B2 expression is important to maintain the mineral homeostasis, its overexpression induced by the depolarization-induced calcium (Ca2+) signaling activation has been reported to increase the synthesis of aldoste...

journal_title：Biochemical and biophysical research communications

authors： Ito R,Morita M,Nakano T,Sato I,Yokoyama A,Sugawara A

更新日期：2021-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignancy with high cancer-associated mortality. Suppressing autophagy has been reported to promote the efficiency of chemotherapy in HCC. Daurisoline (DAS) is a constituent of Rhizoma Menispermi, and functions as a potential autophagy inhibitor to perform different cellular...

journal_title：Biochemical and biophysical research communications

authors： Xue L,Liu P

更新日期：2021-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of insulin-producing β cells. The response of autoreactive T cells to β cell antigens plays a central role in the development of T1D. Recently, fusion peptides composed by insulin C-peptide fragments and other proteins were reported as β cell target ...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto Y,Kishida K,Matsumoto M,Matsuoka S,Kohyama M,Suenaga T,Arase H

更新日期：2021-01-01 00:00:00

abstract：:Plants are often exposed not only to short-term (S-) heat stress but also to diurnal long-term (L-) heat stress over several consecutive days; nevertheless, most previous studies of heat tolerance have used S-heat stress, such as 42 °C for 30-60 min, for evaluation. Yet the mechanisms underlying L-heat tolerance remai...

journal_title：Biochemical and biophysical research communications

authors： Ono M,Isono K,Sakata Y,Taji T

更新日期：2021-01-01 00:00:00

abstract：:Here, we demonstrate that interleukin-1β (IL-1β) contributes to the γ-ionizing radiation (IR)-induced increase of migration/invasion in A549 lung cancer cells, and that this occurs via RIP1 upregulation. We initially observed that the protein expression and secreted concentration of IL-1β were increased upon exposure ...

journal_title：Biochemical and biophysical research communications

authors： Kang AR,Cho JH,Lee NG,Kwon JH,Song JY,Hwang SG,Jung IS,Kim JS,Um HD,Oh SC,Park JK

更新日期：2021-01-01 00:00:00

abstract：:Bile acids have recently emerged as key metabolic hormones with beneficial impacts in multiple metabolic diseases. We previously discovered that hepatic bile acid overload distally modulates glucose and fatty acid metabolism in adipose tissues to exert anti-obesity effects. However, the detailed mechanisms that explai...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Choi JM,Jung SY,Cox AR,Hartig SM,Moore DD,Kim KH

更新日期：2021-01-01 00:00:00

abstract：:The role of microRNAs (miRNAs) in how microbiota influence the host intestinal immune system is not fully understood. We compared the expression profiles of miRNAs and mRNAs in lamina propria leukocytes (LPL) in the large intestines of germ-free (GF) and specific pathogen-free (SPF) mice. Microarray analysis revealed ...

journal_title：Biochemical and biophysical research communications

authors： Ohsaka F,Karatsu Y,Kadota Y,Tochio T,Takemura N,Sonoyama K

更新日期：2021-01-01 00:00:00

abstract：:Virosomes as membranous vesicles with viral fusion protein in their membrane are versatile vehicles for cargo delivery. The vesicular stomatitis virus glycoprotein (VSV-G) is a common fusogenic protein used in virosome preparation. This glycoprotein has been used in liposomal systems so far, but in this study, we have...

journal_title：Biochemical and biophysical research communications

authors： Asadikaram G,Poustforoosh A,Pardakhty A,Torkzadeh-Mahani M,Nematollahi MH

更新日期：2021-01-01 00:00:00

abstract：:DNase coatings show great potential to prevent biofilm formation in various applications of the medical implant, food and marine industry. However, straightforward and quantitative methods to characterize the enzymatic activity of these coatings are currently not available. We here introduce the qDNase assay, a quanti...

journal_title：Biochemical and biophysical research communications

authors： Van der Gucht M,Aktan MK,Hendrix H,Velde GV,Paeshuyse J,Braem A,Lavigne R

更新日期：2021-01-01 00:00:00

abstract：:Inflammation has an essential role in regulating the pathogenesis of acute respiratory distress syndrome (ARDS). The serine/threonine kinase PIM2 is highly expressed in human macrophages, and exhibits regulatory role in inflammatory response. However, its effect on ARDS progression has not been investigated and still ...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Xu L,Dong G,Zhu M,Liu L,Wang B

更新日期：2020-12-17 00:00:00

abstract：:Cognitive impairment, acute or long-term, is a common complication in patients with severe bacterial infection. However, the underlying mechanisms are not fully verified and effective medicine is not available in clinics. Interferon gamma (IFNγ) is a pivotal cytokine against infection and is believed to be a tune in h...

journal_title：Biochemical and biophysical research communications

authors： Lu Y,Yang Y,Peng Z,Xie L,Zhong X,Liang F,Yuan C,Lu B

更新日期：2020-12-17 00:00:00

abstract：:Activation of seven-transmembrane G-protein coupled receptor (GPCR) mediates extracellular signals into intracellular responses. G-protein coupled receptor 55 (GPR55) is one of GPCRs and activated by endogenous cannabinoids. A family of regulators of G-protein signaling (RGS) stimulates GTP hydrolysis of alpha subunit...

journal_title：Biochemical and biophysical research communications

authors： Jang H,Kim Y,Ghil S

更新日期：2020-12-17 00:00:00

abstract：:Zebrafish have high regenerative ability in several organs including the fin. Although various mechanisms underlying fin regeneration have been revealed, some mechanisms remain to be elucidated. Recently, extracellular vesicles (EVs) have been the focus of research with regard to their role in cell-to-cell communicati...

journal_title：Biochemical and biophysical research communications

authors： Ohgo S,Sakamoto T,Nakajima W,Matsunaga S,Wada N

更新日期：2020-12-17 00:00:00

abstract：:Spiroplasma are wall-less bacteria which belong to the phylum Tenericutes that evolved from Firmicutes including Bacillus subtilis. Spiroplasma swim by a mechanism unrelated to widespread bacterial motilities, such as flagellar motility, and caused by helicity switching with kinks traveling along the helical cell body...

journal_title：Biochemical and biophysical research communications

authors： Takahashi D,Fujiwara I,Miyata M

更新日期：2020-12-17 00:00:00

abstract：:The small GTPase Rheb binds and activates mTORC1, which plays a pivotal role in diverse cellular physiologies. To increase our understanding of how Rheb regulates mTORC1 signaling, we set out to identify Rheb binding proteins using shotgun proteomics approaches. In this study, we characterized HSP70, one of the identi...

journal_title：Biochemical and biophysical research communications

authors： Ryu HH,Ha SH

更新日期：2020-12-17 00:00:00

abstract：:Ovarian cancer is a gynecological cancer that has the highest mortality rate and is often resistant to conventional treatments. Therefore, development of new therapies is essential. Metformin (MET), which is the priority drug for treatment of type 2 diabetes, has received increasing attention because of its anti-tumor...

journal_title：Biochemical and biophysical research communications

authors： Cui Y,Zhou J,Rong F

更新日期：2020-12-17 00:00:00

abstract：:The organisms have the capacity to sense and adapt to their surroundings for their life in a dynamic environment. In response to amino acid starvation, cells activate a rectifying physiological program, termed the integrated stress response (ISR), to restore cellular homeostasis. General controlled non-repressed (GCN2...

journal_title：Biochemical and biophysical research communications

authors： Kim K,Park JE,Yeom J,Park N,Trần TT,Kang MJ

更新日期：2020-12-17 00:00:00