Evidence for a regulatory action of vanadate on protein phosphorylation in brain microvessels.

abstract：:To investigate the role of myotonin-protein kinase (MT-PK) in the pathophysiology of myotonic dystrophy (DM), we developed specific antibodies against synthetic MT-PK peptides. The antibody identified a 53kDa protein in skeletal muscle and recognized decreases in the amount of the protein in both adult and congenital ...

journal_title：Biochemical and biophysical research communications

authors： Koga R,Nakao Y,Kurano Y,Tsukahara T,Nakamura A,Ishiura S,Nonaka I,Arahata K

更新日期：1994-07-15 00:00:00

abstract：:We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet p...

journal_title：Biochemical and biophysical research communications

authors： Noda S,Mashima Y,Obazawa M,Kubota R,Oguchi Y,Kudoh J,Minoshima S,Shimizu N

更新日期：2000-10-05 00:00:00

abstract：:The membrane of mouse neuroblastoma N-18 cells degraded dynorphin-(1-13), dynorphin-(1-17), and Leu-enkephalin. The degradation of the former two peptides was inhibited strongly by N-ethylmaleimide, moderately by diisopropylphosphorofluoridate and phosphoramidon, and slightly by bestatin. When Leu-enkephalin was the s...

journal_title：Biochemical and biophysical research communications

authors： Satoh M,Yokosawa H,Ishii S

更新日期：1986-10-15 00:00:00

abstract：:Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits. To understand the molecular basis for the enhanced sensitivity of neurons to CPT, we examined the effec...

journal_title：Biochemical and biophysical research communications

authors： Rossi SL,Lumpkin CJ,Harris AW,Holbrook J,Gentillon C,McCahan SM,Wang W,Butchbach MER

更新日期：2016-10-14 00:00:00

abstract：:Monoclonal antibody prepared against highly purified rat liver G6PD was used to probe the mode of regulation of this enzyme in a mammalian model system. Material cross-reacting with antibody against liver G6PD was found in similar amounts in extracts of two genetically related rat hepatoma cell lines, only one of whic...

journal_title：Biochemical and biophysical research communications

authors： Dao ML,Johnson BC,DeLuca C

更新日期：1984-02-14 00:00:00

abstract：:Regulatory T cells (Treg cells) are crucial for the maintenance of immunological tolerance, and it has been reported that Treg cells are enriched within the tumor micro-environment for immune evasion due to their immunosuppressive functions. To inhibit Treg cells functions, FoxP3, a lineage-specific transcription fact...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Ko JS,Shin Y,Cho JY,Oh HA,Bothwell AL,Lee SK

更新日期：2014-08-15 00:00:00

abstract：:Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and en...

journal_title：Biochemical and biophysical research communications

authors： Lu S,Xu D

更新日期：2013-12-06 00:00:00

abstract：:Betaine Aldehyde Dehydrogenase (betaine aldehyde: NAD(P)+ oxidoreductase, (E.C. 1.2.1.8; BADH) catalyze the irreversible oxidation of betaine aldehyde (BA) to glycine betaine (GB) and is essential for polyamine catabolism, γ-aminobutyric acid synthesis, and carnitine biosynthesis. GB is an important osmolyte that regu...

journal_title：Biochemical and biophysical research communications

authors： Rosas-Rodríguez JA,Soñanez-Organis JG,Godoy-Lugo JA,Espinoza-Salazar JA,López-Jacobo CJ,Stephens-Camacho NA,González-Ochoa G

更新日期：2017-08-26 00:00:00

abstract：:By using a 45Ca2+ overlay technique, we found two calcium-binding proteins (CaBPs) abundant in bovine amniotic fluid, and named them CAAF1 (calcium-binding protein in amniotic fluid-1) and CAAF2. CAAF1 was identified as a novel S100 protein produced by fetal epidermal keratinocytes, squamous epithelial cells and polym...

journal_title：Biochemical and biophysical research communications

authors： Hitomi J,Maruyama K,Kikuchi Y,Nagasaki K,Yamaguchi K

更新日期：1996-11-21 00:00:00

abstract：:The availability of a human lymphoma cell line deficient in adenosine deaminase, adenosine kinase and methylthioadenosine phosphorylase enabled us to compare the effects of nucleoside transport inhibitors on the excretion of endogenously generated adenosine, deoxyadenosine and 5'-methylthioadenosine. The nucleoside tr...

journal_title：Biochemical and biophysical research communications

authors： Iizasa T,Kubota M,Carson DA

更新日期：1984-06-15 00:00:00

abstract：:An endopeptidase capable of metabolizing a number of neuropeptides and generating [Met5] and [Leu5] enkephalin from enkephalin-containing peptides is secreted by glioma C6 cells. This neutral endopeptidase that is likely to be a thiol protease, has a Mr of 71KDa and is effective only towards oligopeptides. Its specifi...

journal_title：Biochemical and biophysical research communications

authors： Ferro ES,Tambourgi DV,Gobersztejn F,Gomes MD,Sucupira M,Armelin MC,Kipnis TL,Camargo AC

更新日期：1993-02-26 00:00:00

abstract：:In this study, acetosyringone was identified as one of the major extracellular phenolics in tobacco suspension cells and was shown to have bioactive properties that influence early events in plant-bacterial pathogenesis. In our model system, tobacco cell suspensions treated with bacterial isolate Pseudomonas syringae ...

journal_title：Biochemical and biophysical research communications

authors： Baker CJ,Mock NM,Whitaker BD,Roberts DP,Rice CP,Deahl KL,Aver'yanov AA

更新日期：2005-03-04 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) are produced as progenitor toxin complexes (PTCs) by Clostridium botulinum. The PTCs are composed of BoNT and non-toxic neurotoxin-associated proteins (NAPs), which serve to protect and deliver BoNT through the gastrointestinal tract in food borne botulism. HA33 is a key NAP component tha...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lam KH,Kruel AM,Perry K,Rummel A,Jin R

更新日期：2014-04-04 00:00:00

abstract：:Malaria, a disease accounting for more than one million deaths per year, is caused by intraerythrocytic growth of Plasmodia. Parasitemia may be blunted by suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and phosphatidylserine exposure. Triggers of eryptosis include lead nitrate (Pb(NO...

journal_title：Biochemical and biophysical research communications

authors： Koka S,Huber SM,Boini KM,Lang C,Föller M,Lang F

更新日期：2007-11-23 00:00:00

abstract：:A new enzyme, tetrahydromethanopterin methyltransferase, which catalyzes the transfer of methyl groups from methyl-tetrahydromethanopterin to 2-mercaptoethane-sulfonate, has been found in the methane synthesizing complex of Methanobacterium thermoautotrophicum. The enzyme is oxygen sensitive and has a well defined pH ...

journal_title：Biochemical and biophysical research communications

authors： Sauer FD

更新日期：1986-04-29 00:00:00

abstract：:cGMP-Phosphodiesterase 6 (PDE6) is the central effector enzyme in the phototransduction system of vertebrate photoreceptors. We have recently found that PDE6 accumulates in a detergent-resistant membrane (DRM) fraction in response to excitation of bovine rod phototransduction system. Here, we studied the molecular mec...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Seno K,Hayashi F

更新日期：2003-03-28 00:00:00

abstract：:The Ca(2+)-binding proteins regulate a number of cellular and extracellular activities and deregulations of S100 gene expression are associated with several human diseases. For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis. We purified human S100...

journal_title：Biochemical and biophysical research communications

authors： Bürgisser DM,Siegenthaler G,Kuster T,Hellman U,Hunziker P,Birchler N,Heizmann CW

更新日期：1995-12-05 00:00:00

abstract：:"Activated" glucocorticoid-receptor complexes purified about 3,000-fold from rat liver were found to bind to histone-agarose. Because of their tight binding, they could not be eluted from the column by high salt solution (3 M KCl) or low salt plus polyol buffer (50% ethylene glycol), but their binding could be disrupt...

journal_title：Biochemical and biophysical research communications

authors： Ueda K,Isohashi F,Okamoto K,Kokuhu I,Kimura K,Yoshikawa K,Sakamoto Y

更新日期：1988-03-15 00:00:00

abstract：:We investigated the presence of the carbohydrate ligand for E-selectin on the cell surface of rat polymorphonuclear leukocytes (PMN). Rat PMN, isolated from peripheral blood, adhered to recombinant rat E-selectin-coated microplates. The adhesion was inhibited either by an anti-rat E-selectin monoclonal antibody (MAb),...

journal_title：Biochemical and biophysical research communications

authors： Misugi E,Kawamura N,Imanishi N,Tojo SJ,Morooka S

更新日期：1995-10-13 00:00:00

abstract：:Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the f...

journal_title：Biochemical and biophysical research communications

authors： Luo J,Zhang L,Stenn K,Prouty S,Parimoo S

更新日期：2005-02-04 00:00:00

abstract：:A ferric low-spin species with an anomalously small g3-g1 separation generated by the reaction of Fe(III)tetraphenylporphyrin with t-butylhydroperoxide in the presence of tatramethylammonium hydroxide was characterized by ESR spectroscopy. The reaction kinetics, investigated by monitoring ESR intensity, indicated that...

journal_title：Biochemical and biophysical research communications

authors： Tajima K,Ishizu K,Sakurai H,Ohya-Nishiguchi H

更新日期：1986-03-28 00:00:00

abstract：:TGFbeta is of crucial importance during transdifferentiation of resting retinoid-storing hepatic stellate cells (HSC) to extracellular matrix producing myofibroblasts (MFB) and consequently, inhibition of TGFbeta signal transduction is an effective means for preventing experimental fibrosis. We have shown that isolate...

journal_title：Biochemical and biophysical research communications

authors： Dooley S,Streckert M,Delvoux B,Gressner AM

更新日期：2001-05-11 00:00:00

abstract：:We measured the amounts of total A beta, A beta 1-40 and A beta 1-42/43 in brain tissues using a newly developed ELISA assay and found that the amounts of insoluble A beta 1-42/43 and insoluble A beta 1-40 were linearly related to the amount of A beta deposits or total insoluble A beta at their lower and higher concen...

journal_title：Biochemical and biophysical research communications

authors： Tamaoka A,Kondo T,Odaka A,Sahara N,Sawamura N,Ozawa K,Suzuki N,Shoji S,Mori H

更新日期：1994-11-30 00:00:00

abstract：:Enhanced formation and accumulation of advanced glycation endproducts (AGE's) have been proposed to play a major role in the pathogenesis of diabetic complications, aging, atherosclerosis, and Alzheimer disease leading to progressive and irreversible intermolecular protein crosslinkings. This process is accelerated in...

journal_title：Biochemical and biophysical research communications

authors： Rahbar S,Kumar Yernini K,Scott S,Gonzales N,Lalezari I

更新日期：1999-09-07 00:00:00

abstract：:Although the introduction of cyclosporine A (CyA) and FK506 for immunosuppressive therapy has dramatically enhanced the early survival of organ transplant recipients, administration of these immunosuppresants is correlated with high incidence of transplant arteriosclerosis. Transplant-associated arteriosclerosis is be...

journal_title：Biochemical and biophysical research communications

authors： Sata M,Walsh K

更新日期：1999-09-24 00:00:00

abstract：:Despite decades of intensive studies, the failure to identify plasmodesmata (PD) localization sequences has constrained our understanding of Tobacco mosaic virus (TMV) movement. Recently, we identified the first PD localization signal (major PLS) in the TMV movement protein (MP), which encompasses the first 50 amino a...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Huang C,Zeng J,Yu H,Li Y,Yuan C

更新日期：2020-01-01 00:00:00

abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

journal_title：Biochemical and biophysical research communications

authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

更新日期：2008-10-03 00:00:00

abstract：:The corticotropin releasing factor (CRF) plays a central role in regulating the activities of hypothalamic-pituitary-adrenal (HPA) axis in the presence of a variety of stressful stimuli via binding to its type 1 receptors (CRFR1). Despite that many peptidic or non-peptidic antagonists of CRFR1 have been developed to s...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Zhuo R,Peng P,Liu X,Yan H,Zhang S,Zheng J,Wei X,Ma X

更新日期：2015-07-31 00:00:00

abstract：:We established two monoclonal antibodies (mAbs) which specifically recognize human 'functionally inactive' recombinant IL-18, and IL-18 protein polymorphism was examined using human monocytes and macrophages (M phi). In 6 day GM-CSF-treated M phi, an 'inactive' IL-18-recognizing mAb 21 detected the IL-18 proform (24 k...

journal_title：Biochemical and biophysical research communications

authors： Kikkawa S,Matsumoto M,Shida K,Fukumori Y,Toyoshima K,Seya T

更新日期：2001-02-23 00:00:00

abstract：:Leukotrienes play an important pathophysiological role in chronic inflammatory states and, as previously shown, cause increased levels of cyclooxygenase-2 (COX-2) in intestinal epithelial cells. The anti-apoptotic protein Bcl-2 is also elevated by LTD(4) stimulation, and in colon cancer, so we studied the mechanisms o...

journal_title：Biochemical and biophysical research communications

authors： Wikström K,Ohd JF,Sjölander A

更新日期：2003-03-07 00:00:00