Myocilin expression in the astrocytes of the optic nerve head.

Abstract:

:We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet portion of the processes of astrocytes adjacent to the inner limiting membrane and blood vessel wall. The astrocytes are the major cell population in the optic nerve head, contributing to the architecture of the nerve axon and blood vessels. Therefore, myocilin gene mutation and change of myocilin protein are likely to affect the architecture of the optic nerve head and induce various forms of glaucomatous optic nerve damage.

authors

Noda S,Mashima Y,Obazawa M,Kubota R,Oguchi Y,Kudoh J,Minoshima S,Shimizu N

doi

10.1006/bbrc.2000.3591

subject

Has Abstract

pub_date

2000-10-05 00:00:00

pages

1129-35

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)93591-5

journal_volume

276

pub_type

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