Abstract:
:We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet portion of the processes of astrocytes adjacent to the inner limiting membrane and blood vessel wall. The astrocytes are the major cell population in the optic nerve head, contributing to the architecture of the nerve axon and blood vessels. Therefore, myocilin gene mutation and change of myocilin protein are likely to affect the architecture of the optic nerve head and induce various forms of glaucomatous optic nerve damage.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Noda S,Mashima Y,Obazawa M,Kubota R,Oguchi Y,Kudoh J,Minoshima S,Shimizu Ndoi
10.1006/bbrc.2000.3591subject
Has Abstractpub_date
2000-10-05 00:00:00pages
1129-35issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(00)93591-5journal_volume
276pub_type
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