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Desmoglein genes are up-regulated in the pk mutant mouse.

Abstract：

:Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the follicular canal. We mapped the pk mutant phenotype to a 1.1cM region of chromosome 18 (between 6.6 and 7.7 cM from the centromere) using 370 backcross progeny. Within this region, among others, are genes for desmosome cadherins. Desmosome cadherins are interesting candidates because of their critical roles for cell-cell adhesion in epidermal function. Northern Blot analysis of wild-type and pk mutant mice indicates that expression of both desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) is up-regulated in the skin of mutant pk mice.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Luo J,Zhang L,Stenn K,Prouty S,Parimoo S

doi

10.1016/j.bbrc.2004.11.136

subject

Has Abstract

pub_date

2005-02-04 00:00:00

pages

64-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02725-1

journal_volume

327

pub_type

杂志文章

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