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Drosophila CK2 phosphorylates Hairy and regulates its activity in vivo.

Abstract：

:Hairy is a repressor that regulates bristle patterning, and its loss elicits ectopic bristles (neural hyperplasia). However, it has remained unknown whether Hairy is regulated by phosphorylation. We describe here the interaction of protein kinase CK2 and Hairy. Hairy is robustly phosphorylated by the CK2-holoenzyme (CK2-HoloE) purified from Drosophila embryos, but weakly by the catalytic CK2alpha-subunit alone, suggesting that this interaction requires the regulatory CK2beta-subunit. Consistent with this, Hairy preferentially forms a direct complex with CK2-HoloE. Importantly, we demonstrate genetic interactions between CK2 and hairy (h). Thus, flies trans-heterozygous for alleles of CK2alpha and h display neural hyperplasia akin to homozygous hypomorphic h alleles. In addition, we show that similar phenotypes are elicited in wild-type flies upon expression of RNAi constructs against CK2alpha/beta, and that these defects are sensitive to h gene dosage. Together, these studies suggest that CK2 contributes to repression by Hairy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kahali B,Trott R,Paroush Z,Allada R,Bishop CP,Bidwai AP

doi

10.1016/j.bbrc.2008.06.084

subject

Has Abstract

pub_date

2008-09-05 00:00:00

pages

637-42

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01259-X

journal_volume

373

pub_type

杂志文章

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