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Overexpression of hepatitis delta antigen protects insect cells from baculovirus-induced cytolysis.

Abstract：

:Hepatitis delta virus (HDV) is a human pathogen causing fulminant hepatitis and liver cirrhosis. HDV has a circular single-stranded RNA genome, which encodes only a single protein, hepatitis delta antigen (HDAg), from the antigenomic strand. Although the functional roles of HDAg have been extensively studied, the molecular mechanism of persistent infection and pathogenesis of HDV are not yet understood. Here we report that overexpressed HDAg protects cells from death in baculovirus-infected insect cells. Using both wild-type and recombinant baculovirus-infected insect cells, we have demonstrated that HDAg inhibited wild-type baculovirus-induced cytolysis and thus extended the survival of virus-infected insect cells. By deletion analysis, we show that N-terminal 25 amino acids are essential for this function. From these data, we suggest that HDAg may play a major role in persistent infection of HDV.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hwang SB,Park KJ,Kim YS

doi

10.1006/bbrc.1998.8317

subject

Has Abstract

pub_date

1998-03-27 00:00:00

pages

652-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98317-6

journal_volume

244

pub_type

杂志文章

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