Induction of ornithine decarboxylase activity in mouse tissues by phorbol ester is effectively blocked by methylglyoxal bis(butylamidinohydrazone).

abstract：:Glutamate-gated chloride (GluCl) channels are pentameric receptors for the inhibitory neurotransmitter glutamate in invertebrates and are a major target for macrolide anthelmintics. Three amino acids in GluCl channels are reported to render macrolide resistance in nematodes and insects. To examine whether these three ...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Sawa Y,Matsuda K,Ozoe F,Ozoe Y

更新日期：2012-03-16 00:00:00

abstract：:Insulin and glucagon secretion from the islets of Langerhans is highly regulated. Although an increased plasma glucose level is the major stimulus for insulin exocytosis, roles for glutamine and glutamate have been suggested. Interestingly, the islet cells display elements associated with synaptic transmission. In the...

journal_title：Biochemical and biophysical research communications

authors： Gammelsaeter R,Jenstad M,Bredahl MK,Gundersen V,Chaudhry FA

更新日期：2009-04-10 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of authors. The Journal received an expression of concern from a reader, which noted that: “The problem is that there is no IL-26 gene in t...

journal_title：Biochemical and biophysical research communications

authors： Bao J,Lv Z,Wang S

更新日期：2018-05-23 00:00:00

abstract：:Saposins (SAPs) are small glycoproteins required for activation of sphingolipid hydrolysis by lysosomal enzymes. Four SAPs, SAP-A, -B, -C, and -D, are proteolytically cleaved from a single gene product termed prosaposin. The mature coding sequence of human SAP-A tagged with 6-histidine was expressed in Pichia pastoris...

journal_title：Biochemical and biophysical research communications

authors： Yamada M,Inui K,Hamada D,Nakahira K,Yanagihara K,Sakai N,Nishigaki T,Ozono K,Yanagihara I

更新日期：2004-05-28 00:00:00

abstract：:We have previously reported that alpha-fetoprotein (AFP) inhibits infection of human monocyte-derived macrophages (MDM) by R5-HIV-1 strains and that a peptide mimicking the clade B HIV-1 gp120 consensus V3 domain (V3Cs) binds to CCR5. We demonstrate here that AFP binds high- and low-affinity binding sites of MDM, char...

journal_title：Biochemical and biophysical research communications

authors： Atemezem A,Mbemba E,Marfaing R,Vaysse J,Pontet M,Saffar L,Charnaux N,Gattegno L

更新日期：2002-08-23 00:00:00

abstract：:Branched-chain alpha-keto acid dehydrogenase (BCKDH) complex catalyzes the committed step of branched-chain amino acid catabolism, and its activity is regulated by the phosphorylation-dephosphorylation cycle. BCKDH kinase is responsible for inactivation of the complex by phosphorylation. In the present study, we exami...

journal_title：Biochemical and biophysical research communications

authors： Xu M,Nagasaki M,Obayashi M,Sato Y,Tamura T,Shimomura Y

更新日期：2001-09-28 00:00:00

abstract：:Tissue transglutaminase (tTgase) contributes to the organisation of the basement membrane and is therefore thought to be important for the integrity and stability of the vessel wall. In the present study, we hypothesised that the HMG-CoA reductase inhibitor atorvastatin may up-regulate the tTgase expression in endothe...

journal_title：Biochemical and biophysical research communications

authors： Soehnlein O,Eskafi S,Schmeisser A,Kloos H,Daniel WG,Garlichs CD

更新日期：2004-09-10 00:00:00

abstract：:Bcl-2 plays a pivotal role in the control of cell death and is down-regulated in trichosanthin (TCS)-induced cell apoptosis. Because Bcl-2 expression is regulated by the transcription factor cyclic AMP response element-binding protein (CREB), we investigated the role of CREB activation in TCS-induced Hela cells apopto...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Yan H,Li JC

更新日期：2007-11-09 00:00:00

abstract：:Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation ...

journal_title：Biochemical and biophysical research communications

authors： Ni B,Farrar JS,Chen S,Lownik JC,Celi FS

更新日期：2018-07-02 00:00:00

abstract：:Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cervical cancers and has great potential therapeutic value. We show that tigecycline, a FDA-approved antibiotic drug, targets cervical squamous cell carcinoma through inhibiting Wnt/β-catenin signaling pathway. Tigecycline is effective in in...

journal_title：Biochemical and biophysical research communications

authors： Li H,Jiao S,Li X,Banu H,Hamal S,Wang X

更新日期：2015-11-06 00:00:00

abstract：:Genetic mutation is one of the causative factors for idiopathic progressive hearing loss. A patient with late-onset, moderate, and high-frequency hearing loss was found to have a novel, heterozygous KCNQ4 mutation, c.806_808delCCT, which led to a p.Ser260del located between S5 and the pore helix (PH). Molecular modeli...

journal_title：Biochemical and biophysical research communications

authors： Watabe T,Matsunaga T,Namba K,Mutai H,Inoue Y,Ogawa K

更新日期：2013-03-15 00:00:00

abstract：:We have designed and constructed a plasmid (pE7RZ-1) that contains a gene for a hammerhead ribozyme that specifically cleaves cottontail rabbit papillomavirus (CRPV) E7 RNA sequences in vitro. The in vitro produced transcripts of pE7RZ-1 cleave CRPV E7 target sequences in trans at 37 degrees C. Pretreatment of pE7RZ-1...

journal_title：Biochemical and biophysical research communications

authors： Wisotzkey JD,Krizenoskas A,DiAngelo S,Kreider JW

更新日期：1993-04-30 00:00:00

abstract：:Structural studies using 500 MHz 1H NMR spectroscopy on Bam H1 recognition site d(GGATCC)2 in solution at 19 degrees is reported. The resonances from the sugar ring and base protons have been assigned from the 2D-COSY and NOESY spectra. Analyses of the NOESY cross-peaks between the base protons H8/H6 and sugar protons...

journal_title：Biochemical and biophysical research communications

authors： Sarma MH,Dhingra MM,Gupta G,Sarma RH

更新日期：1985-08-30 00:00:00

abstract：:miRNA is increasingly being recognized as a key regulator of metabolism in animals. A wealth of evidence has suggested that miRNA mainly binds 3' UTR of mRNA and modulates the cell activities via repressing the mRNA translation. However, as the translation initiates at 5' UTR, cis elements like upstream open reading f...

journal_title：Biochemical and biophysical research communications

authors： Hu W,Wang T,Yang Y,Zheng S

更新日期：2014-09-12 00:00:00

abstract：:Destruxin B, a peptide antibiotic, inhibits vacuolar-type ATPase (V-ATPase) specifically and dose-dependently among ATPases examined. Acidification of intracellular organelles is also blocked by destruxin B at comparable concentrations when assessed by accumulation of acridine orange. The inhibitory activity of destru...

journal_title：Biochemical and biophysical research communications

authors： Muroi M,Shiragami N,Takatsuki A

更新日期：1994-12-15 00:00:00

abstract：:The cell surface receptor integrin is involved in signaling mechanical stresses via the focal adhesion complex (FAC) into the cell. Within FAC, the focal adhesion kinase (FAK) and Pyk2 are believed to act as important scaffolding proteins. Based on the knowledge that many signal transducing molecules are transiently i...

journal_title：Biochemical and biophysical research communications

authors： Klemm AH,Kienle S,Rheinlaender J,Schäffer TE,Goldmann WH

更新日期：2010-03-19 00:00:00

abstract：:In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was screened at middle stringency with a P2Y4 probe. The purification and the sequencing of several clones led us to identify a 984 base pair open reading frame encoding a new human P2Y receptor. It appeared later that this sequence c...

journal_title：Biochemical and biophysical research communications

authors： Communi D,Parmentier M,Boeynaems JM

更新日期：1996-05-15 00:00:00

abstract：:It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the capacity to differentiate into cells of endothelial and hepatocyte lineages. The present study shows that beta-catenin-dependent canon...

journal_title：Biochemical and biophysical research communications

authors： Kordes C,Sawitza I,Häussinger D

更新日期：2008-02-29 00:00:00

abstract：:To date, little is known about the molecular mechanisms controlling the regulation of phospholipase C-delta1 (PLC-delta1) gene expression. To understand the mechanisms responsible for the regulation of PLC-delta1 gene expression, the 5'-flanking region of the mouse PLC-delta1 gene was isolated from a mouse genomic DNA...

journal_title：Biochemical and biophysical research communications

authors： Kim JK,Lee WK,Nam HW,Lee KH,Han H,Rha HK,Jun TY,Kim KS,Choi CR

更新日期：2000-06-24 00:00:00

abstract：:Abnormally expressed long noncoding RNAs (lncRNAs) has been recognized as one of the key source in cardiac diseases. However, the role of lncRNA in doxorubicin (DOX)-induced cardiotoxicity remains largely unknown. In previous studies, we have screened some aberrantly expressed lncRNAs from an animal model for DOX-indu...

journal_title：Biochemical and biophysical research communications

authors： Li J,Li L,Li X,Wu S

更新日期：2018-09-18 00:00:00

abstract：:Hoxc8 is a member of Hox family transcription factors that play crucial roles in spatiotemporal body patterning during embryogenesis. Hox proteins contain a conserved 61 amino acid homeodomain, which is responsible for recognition and binding of the proteins onto Hox-specific DNA binding motifs and regulates expressio...

journal_title：Biochemical and biophysical research communications

authors： Min H,Lee JY,Bok J,Chung HJ,Kim MH

更新日期：2010-02-19 00:00:00

abstract：:Endothelin (200 nM) evoked a rapid rise in [Ca2+]i which was then followed by a maintained elevation of [Ca2+]i. The initial transient can be explained by the release of stored Ca2+ whilst the maintained plateau is likely to be an influx of Ca2+ as it was partially inhibited by nifedipine (5 microM) and the remaining ...

journal_title：Biochemical and biophysical research communications

authors： Simpson AW,Ashley CC

更新日期：1989-09-29 00:00:00

abstract：:Heat shock proteins (HSPs) are involved in protein folding, aggregation, transport and/or stabilization by acting as a molecular chaperone, leading to inhibition of apoptosis by both caspase dependent and/or independent pathways. HSPs are overexpressed in a wide range of human cancers and are implicated in tumor cell ...

journal_title：Biochemical and biophysical research communications

authors： Sarkar R,Mukherjee S,Biswas J,Roy M

更新日期：2012-10-12 00:00:00

abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To elucidate the patterns of transcriptional regulation of these two genes, we performed in silico comparisons of their promoters along with real-time PCR...

journal_title：Biochemical and biophysical research communications

authors： Conner JR,Beisswenger PJ,Szwergold BS

更新日期：2004-10-22 00:00:00

abstract：:3-Hydroxy-3',4'-dimethoxyflavone (HDMF) is a natural chemical product that is not currently regarded as a drug. In our study, we employed glioblastoma cells and cell biology and biochemistry approaches to investigate the potential of HDMF as a natural anticancer therapy option. FACS analysis showed that treatment conc...

journal_title：Biochemical and biophysical research communications

authors： Bae IH,Lee WS,Yun DH,Han YH,Lee JS

更新日期：2014-07-18 00:00:00

abstract：:Recent studies from our laboratory demonstrated that Egr-1 is upregulated in the rat duodenal mucosa during cysteamine-induced duodenal ulceration and that antisense egr-1 oligonucleotide aggravates the duodenal ulcers. This study was aimed to determine the effects of cysteamine on redox-sensitive Egr-1 transcriptiona...

journal_title：Biochemical and biophysical research communications

authors： Khomenko T,Deng X,Jadus MR,Szabo S

更新日期：2003-10-03 00:00:00

abstract：:Burkitt's lymphoma is an aggressive B-cell neoplasm resulting from deregulated c-myc expression. We have previously shown that proliferation of Burkitt's lymphoma cell lines such as Ramos is markedly reduced by iron treatment. It has been shown that iron induces expression of c-myc which, owing to its transcriptional ...

journal_title：Biochemical and biophysical research communications

authors： Habel ME,Jung D

更新日期：2006-03-24 00:00:00

abstract：:In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, sa...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Meng Q,Chen B,Shen H,Yan B,Sun B

更新日期：2016-09-09 00:00:00

abstract：:Ras can become activated via multiple distinct receptors in T lymphocytes. However, mechanistic studies of Ras signaling in normal T cells have been hampered by the lack of an efficient technology for gene transfer into resting post-thymic cells. We have overcome this limitation by utilizing adenoviral transduction of...

journal_title：Biochemical and biophysical research communications

authors： Marks RE,Ho AW,Rivas F,Marshall E,Janardhan S,Gajewski TF

更新日期：2003-12-19 00:00:00

abstract：:Gastrin heptadecapeptides (gastrins I and II which differ in the presence of sulfate on the tyrosine of the latter) have been purified and sequenced from several mammalian species including pig, dog, cat, sheep, cow, human and rat. A 34 amino acid precursor ("big" gastrin), generally accounting for only 5% of total ga...

journal_title：Biochemical and biophysical research communications

authors： Shinomura Y,Eng J,Yalow RS

更新日期：1987-02-27 00:00:00